Formulation and Evaluation of Polyherbal Antimicrobial and Scar Soothing Gel

Abstract

The present study was focused on the formulation and evaluation of a polyherbal antimicrobial and scar soothing gel using natural herbal ingredients such as Neem extract (Azadirachta indica), Aloe vera extract (Aloe barbadensis Miller), and Tea Tree Oil (Melaleuca alternifolia). The objective of the study was to develop a safe, effective, and stable topical herbal formulation possessing antimicrobial, soothing, moisturizing, and wound healing properties for the management of minor skin infections and scar-related conditions.The gel formulation was prepared using Carbopol 940 as a gelling agent along with suitable pharmaceutical excipients including propylene glycol, glycerin, methyl paraben, propyl paraben, disodium EDTA, and triethanolamine. The prepared formulation was evaluated for various physicochemical and microbiological parameters such as appearance, pH, viscosity, spreadability, homogeneity, antimicrobial activity, and stability. The prepared gel exhibited satisfactory physicochemical characteristics including smooth texture, homogeneous appearance, acceptable viscosity, good spreadability, and skin-compatible pH. The antimicrobial study demonstrated significant inhibitory activity against selected microorganisms, which may be attributed to the synergistic action of Neem extract and Tea Tree Oil. Aloe vera contributed to the soothing, moisturizing, anti-inflammatory, and wound healing effects of the formulation.

The stability study indicated that the prepared formulation remained stable during the storage period without significant changes in color, odor, pH, consistency, or homogeneity. The results of the present study suggested that the formulated polyherbal antimicrobial and scar soothing gel may serve as a safe, effective, and natural alternative to synthetic topical preparations used for the treatment of skin infections, wounds, irritation, and scar-related conditions.