Journal for Research in Applied Sciences and Biotechnology

Synergistic Fusion: Enhancing Herbal Potency with Phytosome Technology

Deepshikha Jamloki — 2024-12-21

This review explores the innovative integration of Phytosome technology to augment the effectiveness of herbal compounds. Phytosomes are specialized delivery systems that enhance the bioavailability and absorption of herbal extracts by forming molecular complexes with phospholipids. The review highlights the pivotal role of Phytosomes in improving the solubility and permeability of herbal constituents, thereby facilitating their absorption into the bloodstream. By encapsulating herbal molecules within phospholipid layers, Phytosomes shield them from degradation and metabolic processes, prolonging their presence in the body and enhancing their pharmacological activity. Furthermore, the review underscores the versatility of phytosome technology in enhancing the efficacy of various herbal extracts ranging from traditional remedies to modern herbal supplements. Through case studies and empirical evidence, the paper illustrates how the synergistic fusion of phytosomes with herbal compounds leads to superior therapeutic outcomes compared to conventional formulations.

Moreover, the review discusses the potential applications of synergistic fusion in diverse fields such as pharmaceuticals, nutraceuticals, and cosmeceuticals. It emphasizes the significance of this approach in addressing challenges related to poor bioavilability and inconsistent efficacy encountered with conventional herbal preparations. A comprehensive overview of the synergistic potential of combining phytosome technology with herbal extracts. It elucidates the mechanisms underlying enhanced bioavailability and efficacy, paving the way for the development of novel herbal formulations with optimized therapeutic benefits.

Review on Ketoprofen (Anti-Inflammatory Drug)

Bhupendra Kumar — 2024-12-21

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) widely utilized for its analgesic, anti-inflammatory, and antipyretic properties. This review article examines ketoprofen's pharmacological profile, efficacy, and therapeutic applications, particularly in the management of acute and chronic pain, including dysmenorrhea, osteoarthritis, and rheumatoid arthritis. Ketoprofen exerts its effect by inhibiting the cyclooxygenase (COX) enzymes, COX-1 and COX- 2, reducing the synthesis of prostaglandins responsible for pain and inflammation. Various formulations of ketoprofen are available, including oral tablets, topical gels, suppositories, and injectables, each tailored to specific clinical needs and patient preferences. Recent advancements in topical and extended-release formulations have improved patient adherence and minimized gastrointestinal side effects traditionally associated with NSAIDs. However, ketoprofen remains contraindicated in patients with certain cardiovascular, renal, and gastrointestinal conditions, underscoring the need for careful patient selection and dosage adjustment. This review highlights ketoprofen's clinical efficacy, safety profile, and evolving therapeutic applications, providing insight into its role within the broader scope of pain management strategies.

Review on Medicinal Herbs in the Treatment of Gout

Munna Kumar — 2024-12-21

Joint urate crystals are the hallmark of the inflammatory condition known as gout. Acute gout is characterised by the abrupt development of swelling and pain that begins in the greater toe. This condition is linked to high levels of uric acid in the blood, which can occur when the kidneys do not excrete enough of the acid or when the body produces too much uric acid. Allopurinol, which inhibits the enzyme xanthine oxidase and hence lowers blood uric acid levels, is the mainstay of conventional gout treatment in contemporary medicine. Pain and inflammation can be managed with the help of nonsteroidal anti-inflammatory drugs (NSAIDs). It has also been seen that non-pharmacological approaches, such as dietary improvements, can improve patients' situations. Many people believe that herbal treatments are safer and more effective than conventional pharmaceuticals, especially when it comes to patient adherence and the potential for adverse effects. Celery and parsley, when used together, have demonstrated effects comparable to those of allopurinol. This article's goal is to provide a summary of allopurinol's herbal substitutes.

Varieties and Physical Characteristics of Indigenous Cattle Breeds in Somalia: A Literature Review

Mohamed Ibrahim Abdi - Soojeede — 2024-12-21

The aim of this review was to find out the indigenous Somali cattle breeds in Mogadishu, Somalia and also what is the physical difference between them and what do other scholar wrote about them, this breeds have some unique characteristics and they have one thing in common which is important for pastoralist communities because pastoralists depend on these animals for their livelihood. This study found different types of indigenous breeds including Dawara, Surqo, Gassara, Saywal and Somali Boran those were originated in local community as well as other breeder were hybrid but all of them were resilient and sustainable for local pastoralists. The Somali cattle breeds occupy specific niches in terms of environment and diseases.

They have cultural importance with milk and meat; and play roles in local economies supporting their livelihoods. The Boran breed, said to have originated from the Boran clan in south Ethiopia, is exposed to high temperatures and infectious diseases. They are not only good for meat but also produce substantial amounts of milk. The Gassara breed is smaller than other breeds and has been described as being less productive but able to survive under harsh conditions because they easily adapt and store fat – valuable features during droughts when pastures disappear. Similarly, the Dawara breed plays an important role among some pastoral Somali communities and remains culturally valued by them even though its milk yields have been recorded as being lower than those of other breeds. Saywal cattle is a local variety of the Sahiwal which is both a milk and meat producing breed that originated in India as evidenced by the history of trade activities on the livestock heritages in the region.

The Surqo breed of cattle is a cross-breed between boran and dawara breeds hence their contribution to food security in certain regions of Somalia. Cattle hybrids, on the other hand, introduced in with the help of the Somali government through overseas artificial insemination have higher milk production but take time to adapt with the environment. Therefore, the protection of the genetic resources and unique characteristics of these locally developed breeds is of prerequisite importance to the livelihood of pastoralists and food security in Somalia.

The study recommends establishing artificial insemination centers in all region were dominate with cattle husbandry to produce hybrids that combine the hardiness of local cattle breeds those have desirable productivity characteristics. Additionally, development international collaboration Such as agencies those have skilled in livestock biotechnology and also ability to enhance the effectiveness of breeding programs of cattle. Also make Improve management practices, including the rotational grazing and the development of water resources for rural areas, together with training for pastoralists and agro-pastoralists on modern husbandry techniques, are also essential.

NEP-2020 Awareness among Teachers: A Study of Knowledge, Perceptions and Challenges

Heena — 2024-12-21

New Education Policy 2020 has been announced by honorable Prime Minister of India, Shri Narendra Modi Ji to make India a knowledgeable vibrant country which is a current need of 21st century. The policy aims to promote the role of teachers in Indian society and culture and to develop fundamental skills in students as well as social, ethical, emotional and critical thinking skills in all students. However, there is no sufficient implementation of NEP -2020 yet. This study was conducted to explore the knowledge of teachers about NEP-2020. It was a questionnaire based study consisting of 10 questions. All data were analyzed in MS-Excel, SPSS. A significant proportion of teachers (68%) have foundational knowledge of current educational policy, indicating a basic knowledge that is essential for effective implementation. However, 52% of teachers were not aware about the role of NEP in higher education system, national education schemes. Only 20% of educators express confidence in using these frameworks. Most of the respondents deny to be benefited from National Education Schemes due to lack of awareness, highlighting the critical need for targeted professional development and support. Key gaps in technology integration and policy understanding were identified, highlighting areas where teachers need additional training and resources. Seminars should be organized regularly to keep teachers informed about national programmes and their implementation.

Investigating the Antimicrobial Activity of Derivatives of Benzotriazole

Niranjan Sanjay Chaudhari — 2024-12-21

Benzotriazole derivatives have emerged as a promising class of compounds with significant antimicrobial activity. This review article delves into the diverse antimicrobial properties of benzotriazole derivatives, focusing on their efficacy against various pathogenic microorganisms. We provide a detailed examination of the chemical structure-activity relationship (SAR) of these derivatives, highlighting how modifications to the benzotriazole core influence their antimicrobial potency. The review synthesizes findings from recent studies that explore the mechanisms of action, spectrum of activity, and potential applications of benzotriazole derivatives in combating bacterial, fungal, and viral infections. Additionally, we discuss the challenges and future directions in optimizing these compounds for clinical use, including issues related to toxicity, stability, and formulation. By consolidating current research and identifying key trends, this article aims to offer a comprehensive resource for researchers and pharmaceutical developers interested in harnessing the antimicrobial potential of benzotriazole derivatives.

Non-Linear λ-Jordan Triple Derivation on Prime Algebras

Ahmad Ramin Rahnaward — 2024-11-12

Let A be a prime ∗−algebra and Φ a λ−Jordan triple deriva- tion on A, that is, for every A, B, C ∈ A, Φ(A ⋄ B) = Φ(A) ⋄ B + A ⋄ Φ(B) wher A ⋄_λ B = AB^∗ + λBA such that a real scalar |λ| ̸= 0, 1, and Φ is addi- tive. moreover, if Φ(I) and Φ(il) are selfadjiont then Φ is a ∗−derivation

A Review on Phytochemical and Ethano Pharmacology of Mallotus Philippnensis

Vaishnavi Tripathi — 2024-10-31

Mallotus philippinensis (Lam.) M Arg is a threatened plant species in the central ecoregion. It is a member of the Euphorbiaceae family. Mallotus philippinensis (Lam.) Muell. Arg. (Family: Euphorbiaceae) is a significant perennial plant utilised in traditional medicine. It is primarily prevalent in the tropical and subtropical climates globally. Despite its herbal origin, it is classified within one of the eight Sadharana rasa categories [Glands and hairs of Mallotus philippinensis (Kampillaka), Arsenic (Somala), Ammonium Chloride (Navasagara), Cowri (Kaparda), Amber (Agnijaara), Red Oxide of Mercury (Girisindoora), Cinnabar (Hingula), Litharge (Muddaarashringa)] in Rasa-shastra, the Ayurvedic study of minerals and metals. M. philippinensis is included within Virecana ghana, a group of medicinal plants or items utilised in purgation therapy in Ayurvedic medicine. Primarily, roots, fruits (including fruit powder), and leaves are utilised for therapeutic applications. The leaves possess a bitter flavour and exhibit a cooling, appetising quality. The glands and hairs of the fruit and leaves are advised for cutaneous issues. To date, research investigations have been conducted to validate and examine the pharmacological properties of M. philippinensis. This document aims to summarise the distribution, morphology, Ayurvedic and traditional applications, and scientific research about M. philippinensis. Researchers have empirically demonstrated the antimicrobial, hepatoprotective, anti-leukemic, anti-HIV, anti-inflammatory, anti-filarial, analgesic, hypnotic, antiproliferative, antifertility, purgative, anthelmintic, and antiallergic activities of various parts of M. philippinensis

Digital Twin - An Innovative Strategy in Healthcare Transformation: An Extensive Review

R. Subashini — 2024-12-21

In an age where the physical and digital worlds progressively intersect, the concept of the digital twin has aroused as a transformative force across various industries. Digital twins are dynamic digital imitations of physical objects; systems are procedures that can be used to simulate, analyse, and optimize their real-world analogue. In the health care field, a lot of work has gone into establishing digital twin of patient and medical devices. The digital twin of the patient is created by digitising the patient’s physical traits and bodily alterations. Real-world utilization of this technology includes accurate maintenance, advanced operational efficiency, and support for well-informed decision-making, all of which are trans-formative. The digital twin revolution is changing how healthcare professionals approach patient care, treatment planning, and facility administration. Digital twins provide instantaneous monitoring, personalized therapy, and predictive analytics by generating dynamic virtual replicas of patients, medical equipment, and healthcare systems. By offering insights on energy use, material consumption, and other vital variables, digital twin facilitates improved resource management and boosts businesses by cutting costs and waste. Digital twins are positioned to play a vital role in modern healthcare, inciting innovation and efficiency throughout the sector as technology advances. We focused on applications and development of digital twin in healthcare sector by analyzing a large number of studies from distinct medical sector, the effectiveness of digital twin in imaging studies and diagnosis, cancer, cardiology, neurology has been discussed in this review.

Transdermal Patches: Design and Current Approaches Using Natural Polymers

Aman Kumar — 2024-11-25

One method of controlled drug delivery is the transdermal drug delivery system (TDDS), which aims to distribute the drug through the skin at a predetermined and regulated rate. It provides a number of benefits, including a longer therapeutic impact, fewer side effects, increased bioavailability, better patient compliance, and simple medication therapy discontinuation. For most compounds, the stratum corneum is thought to be the rate limiting barrier in transdermal penetration. The appendageal, transcellular, and intercellular pathways are the three main ways that drugs can enter the body. When giving medication by this route, it is important to take into account the following aspects: skin age, condition, physicochemical characteristics, and environmental conditions. Polymer matrix, membrane, drug, penetration enhancers, pressure-sensitive adhesives, backing laminates, release liner, etc. are some of the fundamental parts of TDDS. Transdermal patches are used to deliver active chemicals to the circulatory system through the skin. These patches can be classified into a variety of systems, such as reservoir, matrix, and micro-reservoir systems. Consistent methodologies are used to assess the adhesion qualities, physicochemical properties, in vitro drug release studies, in vitro skin penetration studies, skin irritation studies, and stability studies once transdermal patches have been prepared. Different medications are marketed as transdermal patches, depending on the length of the therapy. Natural polymers can be used as the means of achieving predetermined rates of drug delivery. Natural polymers are basically polysaccharides so they are biocompatible and without any side effects. Gums, mucilages, resins and plant extracts are widely used natural materials for conventional and novel dosage forms. The present article highlights the available information on natural polymers and their versatile use.

Review on Various Type of Vaccines for Controlling Infectious Disease

Anamika — 2024-11-25

Background: Vaccines have played a critical role in the prevention and treatment of infectious diseases, greatly lowering worldwide morbidity and mortality. This review examines many forms of vaccinations. In contrast, inactivated vaccines, such as the polio vaccine, are safer for immunocompromised people, they frequently require booster shots. Aim: This review emphasises the importance of vaccinations in public health and the need for innovation to tackle future infectious disease threats. The introduction of new pathogens has prompted the creation of novel vaccination platforms, including mRNA and viral vector vaccines. mRNA vaccines, such as those used to treat COVID-19, use genetic instructions to direct cells to manufacture antigens, resulting in strong immunity. Conclusion: These vaccines have demonstrated excellent efficacy and rapid scaling, making them valuable instruments in pandemics. This review emphasises the necessity of designing vaccine methods that meet individual illnesses, demographics, and logistical obstacles. While vaccinations have considerably reduced the occurrence of infectious diseases, more research is needed to address future threats, improve vaccine efficacy, and overcome obstacles such as vaccine reluctance and global inequities. Understanding the capabilities and limits of each vaccine type will help researchers and policymakers better equip healthcare systems to address current and future infectious disease concerns.

Tinospora cordifolia (Giloy): A Review of the Various Pharmacological Pathways of a Highly Potential Medicinal Ayurveda Plant

Amartya Kumar Bhardwaj — 2024-11-25

Tinospora cordifolia, often known as "Amrita" or "Guduchi," is a medication that played a significant role in Indian systems of medicine (ISM) and has been utilised in the treatment of many ailments since the beginning of time. The term "guduchi" comes from the Sanskrit language and translates to "which protects the body from diseases." There is another name for this herb, and that name is "Amrita," which is a reference to the celestial elixir that is described in Hindu mythology. The medication is a well-known Indian bitter that is used for a variety of conditions, including fevers, diabetes, dyspepsia, jaundice, urinary issues, skin illnesses, and frequent diarrhoea and dysentery. Furthermore, it has been demonstrated to be effective in the treatment of cardiovascular disorders, leprosy, helminthiasis, and rheumatoid arthritis syndrome. In addition to being a significant medicine, it is utilised in a variety of preparations, including Satva, Ghrita, Tail, Swarasa, and all of these. An examination of the Charaka Samhita, the Sushruta Samhita, the Ashtanga Hridaya, the Ashtanga Sangraha, the Bhavprakash Nighantu, the Raj Nighantu, the Dhanvantari Nighantu, the Shaligrama Nighantu, the Priya Nighantu, the Kaiydev Nighantu, the Madanpal Nighantu, and the Shodhal Nighantu, as well as the internet and contemporary medical literature, have all been examined for this review article. There was a widespread recognition that the Tinospora cordifolia plant possessed high degrees of medicinal, therapeutic, curative, healing, and alleviating properties. By virtue of its anti-toxic, anti-inflammatory, anti-pyretic, and anti-oxidant qualities, guduchi possesses a significant potential for therapeutic application. Moreover, there is no evidence to suggest that Guduchi contains any hazardous substances or has any adverse effects, which further demonstrates that it is safe to use. Concluding remarks: The medicinal characteristics of the plant Tinospora cordifolia (Giloy) have been confirmed by the studies that were presented in this review. These studies focus on the therapeutic and safety features of the herb, and they demonstrate that it can prevent a variety of diseases or abnormalities by naturally boosting immunity in human bodies.

Artificial Intelligence in Skin Cancer: A Literature Review from Diagnosis to Prevention and Beyond

Khaled Khalifa Said — 2024-11-27

Artificial Intelligence (AI) in medicine is quickly expanding, offering significant potential benefits in diagnosis and prognostication. While concerns may exist regarding its implementation, it is important for dermatologists and dermatopathologists to collaborate with technical specialists to embrace AI as a tool for enhancing medical decision-making and improving healthcare accessibility. This is particularly relevant in melanocytic neoplasms, which continue to present challenges despite years of experience. Dermatology, with its extensive medical data and images, provides an ideal field for training AI algorithms to enhance patient care. Collaborative efforts between medical professionals and technical specialists are crucial in harnessing the power of AI while ensuring it complements and enhances the existing healthcare framework. By staying informed about AI concepts and ongoing research, dermatologists can remain at the forefront of this emerging field and leverage its potential to improve patient outcomes. In conclusion, AI holds great promise in dermatology, especially in the management and analysis of Skin cancer (SC). In this review we strive to introduce the concepts of AI and its association with dermatology, providing an overview of recent studies in the field, such as existing applications and future potential in dermatology.

Advanced SQL Query Techniques for Data Analysis in Healthcare

Sai Krishna Shiramshetty — 2023-08-31

The experts in complex healthcare databases have acknowledged the need for advanced SQL query skills as more significant and diverse datasets grow in the modern healthcare environment. In this paper, core SQL methods including joins, subqueries, and window functions are explained and used for demonstrating the following practical use cases: predictive analytics, cohort analysis, and operational improvement. Several aspects of how SQL works with current and future technologies including, Artificial Intelligence, Cloud Computing, Big Data Solutions are also discussed. Optimizing health care data analysis requires the resolution of issues including date synthesis, security and performance; nevertheless, SQL continues to play a pivotal role in enhancing the analysis of health care data thus leading to improved management and patient care.

Review on Immunological Perspectives and Therapeutic Management Strategies for COVID-19

Rushikesh K. Kakde — 2024-11-27

The global spread of COVID-19 due to SARS-CoV-2 has posed unique challenges to public health. This review was carried out from the perspective of immunological and pathological changes affecting epidemiological features of the disease during progression and therapy. COVID-19 primarily affects the respiratory system but may also affect cardiovascular and neurological systems, manifesting various symptoms from fever and cough to such severe complications as acute respiratory distress syndrome (ARDS) and organ failure. Patterns in immune responses involving decreases in peripheral T cells and natural killer cells have been recognized as being part of a potential biomarker and therapeutic target. Finally, it discusses the dynamic of the transmission of SARS-CoV-2, including droplet mode spread and possible fecal-oral pathway. The virus's structural and pathological attributes are emphasized, complemented by a historical overview that chronicles its transformation from a non-threatening variant to a worldwide hazard. Various management approaches, encompassing traditional Indian medicinal practices and immune-enhancing measures such as zinc, iron, magnesium, vitamins, and herbal treatments, are assessed regarding their effectiveness in bolstering immunity and facilitating recovery. Additionally, lifestyle habits such as physical activity, sufficient rest, and proper hydration contribute to the maintenance of immune health. This extended review presents analyses of SARS-CoV-2 mechanisms of immune alteration and a unified approach toward the understanding and combat of COVID-19.

Integrative Approaches to Climate Change, Urban Expansion, and Sustainable Development: A Global and Interdisciplinary Review

Farham Ahmed — 2024-11-09

This review paper synthesizes findings on the intersection of climate change, urban expansion, demographic transitions, and sustainable development. Using an interdisciplinary approach, this work examines case studies from diverse geographies to explore how rapid urbanization, environmental stress, and technological innovations impact global ecosystems. Our review covers climate-induced migration, land-use changes, groundwater depletion, and sustainable development practices, advocating for integrated policy solutions that align with ecological preservation and social resilience. The findings underscore the need for innovative urban planning, predictive modeling, and community-driven conservation to address complex global challenges.

Cascabela thevetia Ethnobotanical, Phytochemistry, Pharmacological Activities and Medicinal Uses: A Detailed Study

Prakash Pralhad Sarwade — 2024-11-16

There are a few different names for the member of the Apocynaceae family known as Cascabela thevetia. Some of these names include digoxin, lucky nut, and yellow oleander. The lovely and evergreen Cascabela thevetia is a dicotyledonous shrub that is known for its evergreen nature. There are a number of countries in Central and South America, as well as a number of Asian nations, where the Cascabela thevetia plant is indigenous. These countries include India and Sri Lanka. The Cascabela thevetia plant has been found to have a wide variety of secondary metabolites, such as alkaloids, flavonoids, steroids, terpenoids, tannins, saponins, and cardiac glycosides. These plants include a number of cardiac glycosides, including neriifolin, thevetin A, thevetin B, and oleandrin, and each and every one of them is dangerous. The leaves of the plant are used in traditional medicine not just for their alleged medicinal benefits, but also for their diuretic and cardiotonic effects. The pharmacological activity of a number of plant components, including seeds, flowers, bark, fruits, and leaves, has been reported in a number of different experiments. It is common for T. peruviana to be the cause of toxicological emergencies in tropical and subtropical climates all over the world. Numerous cardiac glycosides, including neriifolin, oleandrin, thevetin A, and thevetin B, are discovered in this potentially hazardous plant. These glycosides are only a few examples. After consuming oleander, some of the symptoms that may manifest themselves include hyperkalaemia, nausea, vomiting, diarrhoea, and abdominal pain. Oliander can also cause diarrhoea. The purpose of this review is to provide a comprehensive data collection that includes information on morphology, cultivation and propagation, distribution, phytochemistry, traditional uses, and pharmacological qualities.

Innovative and Biodegradable Sanitary Napkins with Focus on Affordability and Environmental Impact

Shivani P. Chavan — 2024-11-19

The awareness people have towards the environment pollution resulting from the use of the normal sanitary napkins has encouraged production of eco-friendly napkins. Modern ones are largely plastic-wired sanitary napkins constructed with superabsorbent polymers as their major components, which take roughly 500 years to degrade. This presents a major environmental concern, seeing that each woman will use about 11,000 pads in their lifetime and these are bound to a landfill. As a remedy the sanitary napkins that are biodegradable has been developed using banana fiber, bamboo, and polylactic acid derived from cornstarch. The current paper seeks to establish the possibility to use these environmentally friendly products with special emphasis on the cost issues and the impact they would have on the environment. Low cost, high biodegradability, high absorbency, high tensile strength, and possibility for banana fiber in the development region are pointed out. The outcome in terms of banana fiber sheets production as well as their incorporation into Sanitary Napkin were encouraging in respect of absorbency, antibacterial activity and biodegradability. The tests proved that the new biodegradable napkins disintegrate much more quickly than current plastic-based products, in a matter of months, contrary to the centuries that it would take for plastic pads to decompose. This is the reason why current biodegradable napkin products cost more than conventional napkin products as production price is still relatively high; however, measures of procuring locally and constantly improving material processing to manage the cost down are in the works. This research adds for the possibility of biodegradable sanitary napkin to reduce environmental degradation, through the alternative provision of safe and affordable, hygienic menstrual solutions where there are few to non-existent. Such products if further developed and marketed on large scale could be made available and sustainable for people all over the world.

Role of Pyrimidine Derivatives in the Treatment of Cancer

Prakash Pralhad Sarwade — 2024-11-12

The study of the chemistry of pyrimidines is contributing to the expansion of research into the therapeutic applications of these compounds. In the field of medicinal chemistry, the sheer number of pyrimidine synthesis methods and reactions that are available opens up a world of possibilities. These investigations have been inspired by the fact that pyrimidines can be used as building blocks for a wide variety of compounds that have a physiological effect. The pyrimidine ring and its fused derivatives, which include pyrazolo[3,4-d]pyrimidine, pyrido[2,3-d]pyrimidine, quinazoline, and furo[2,3-d]pyrimidine, have garnered a great deal of attention due to the extensive variety of biological potential that they possess. In addition, fused pyrimidines are considered to be bioisosteres with purines. As a consequence of this, numerous substances, such as pyrimidine and derivatives of fused pyrimidine, have demonstrated promising anticancer potential. Pyrimidine compounds have been shown to possess a number of beneficial qualities, including antibacterial, anticancer, anti-inflammatory, antidiabetic, and analgesic effects. The purpose of this study is to shed light on the anticancer significance of certain fused pyrimidine derivatives and privileged pyrimidines through the use of various types of inhibition. Additionally, the study reveals structure-activity relationships and provides specifics regarding the synthetic compounds that were utilized in the construction of these scaffolds. The hope is that this research will assist medicinal chemists in the development of highly selective pyrimidine anticancer agents. The focus of this review article is on recent research on synthetic pyrimidine compounds that have anticancer effects. Additionally, the paper examines the chemistry and biological activities of pyrimidines.

Adversarial Machine Learning Approaches for Strengthening Cybersecurity in Intrusion Detection Systems

Rahul Gandhi — 2023-10-31

In this study, adversarial machine learning to enhance IDS’s capability to counterattack sophisticated cyberattacks employed in the investigation. This paper describes challenges in practice of adversarial techniques, performance measurement and ethical issues. In the research proposal, the authors describe the comprehensive and multi-level method of detecting artifacts, building complex models, and gathering data. Researchers stressed important conclusions regarding aggressiveness of privacy-preserving methods, the need for developing new performance metrics, and the tension between robust model and detection performance. The research assists in developing IDS that are both efficient and formally correct in various contexts of a network.

Real-Time Data Pipelines for Feature Stores in Gaming

Robin Gupta — 2023-10-31

Machine learning models are used in content creation and generate real-time observations in gaming with a positive effect on both performance and production processes. However, the management and deployment of these features and metrics for the purposes of these benefits are critical. Looking at feature and metric stores data structures that are used for storing and retrieving feature and metric data for machine learning models. Feature stores are responsible for featuring storage and delivery for model training and features needed for model’s inferencing, whereas metric stores contain metrics required for the assessment of specific models. The adoption of these stores can drastically bring down the amount of development time and effort as well as enhance the aptitude of recognizing real time actions and quality of the game. It is therefore prudent and helpful for the reader to learn the basic concepts that underpin feature and metric store, the ways in which gaming application benefits from them, and the possible ways in which this technology can be developed further in the future.

Machine Learning on Encrypted Data: Analyzing Efficiency and Accuracy Trade-Offs

Kavitha Kumari — 2023-08-31

In this modern era, phishing has become a great problem. Because of this, it can be observed that the personal information of people is leaked from emails & websites. Hence, it is needed that these instances of phishing are to be reduced. In doing one of the best tools that can be used is Machine Learning. This is a process of using historical data for making prediction of future scenarios. In this project, the details of the approached that can be used for the detection of phishing are analyzed. Moreover, the algorithms that are used by ML for this purpose are also envisaged here. The description of the process of collection of data is presented here. In addition to this, the results that shows the effectiveness of ML in the detection of phishing is also discussed here.

Federated Learning in Privacy-Preserving Machine Learning: Balancing Model Accuracy and Data Security

Rajeev Agarwal — 2023-08-31

This research article provides information regarding the concerns of Privacy-Preserving Machine Learning (PPML) Techniques that includes Differential Privacy, Federated Learning, and Secure Multi-Party Computation. It is also noticed that Privacy Models are useful to achieve significant privacy and minimal loss in model accuracy. This further demonstrates that these kinds of strategies in the main application areas such as Healthcare, Banking, Internet-Of-Things (IOT), and Manufacturing, provides near-perfect privacy that can be useful while it meets minimal compromise in model accuracy. Some of the findings are enhanced data security, high accuracy of the chosen model, and ideas for future development.

Chronic Obstructive Pulmonary Disease (COPD): Diagnosis, Pathology, Clinical Presentation and Homoeopathic Management

Praveen Kumar Pathak — 2024-10-31

Chronic Obstructive Pulmonary Disease (COPD) is a very common problem worldwide now a day. COPD is preventable and treatable disease it is characterized by constant airflow limitation that is generally progressive and connected with an enhanced chronic inflammatory response in the airways and the lung to noxious particles or gases. Exacerbations and comorbidities contribute to the generally severity in individual patients of COPD. It remains a most important reason of morbidity and mortality globally and outcome in an economic and social burden that is both substantial and increasing.

The Impact of Pesticides on Groundwater Quality

Sumaya Assanousi Eshtiwi Lama — 2022-04-30

Pesticides have gotten to be exceptionally advantageous to agriculturists and to other individuals around the world as they can increment edit surrender and can give a number of other benefits or focal points to everybody straightforwardly or in a roundabout way. But due to dangers forced by the pesticides on environment and human wellbeing; concerns are raised around its security. The utilize of pesticides is causing genuine wellbeing impacts. Indeed at less concentration, pesticides are a major risk to environment. The pesticides are sullying water bodies and are causing water contamination. Be that as it may, the dangers of pesticides can't be dispensed with totally but they can outwit in another way. Able to minimize the hurtful or unfavorable impacts of pesticides by different ways like by applying elective trimming methods or through superior splashing equipment's.

Detailing of secure, way better and eco-friendly pesticides can reduce the unfavorable impacts related to utilize of pesticides. The chance of pesticides can be diminished in the event that we utilize pesticides in reasonable sum and utilize them as it were when essential or required.

Numerous individuals or agriculturists are not mindful of the harmfulness or destructive impacts of pesticides. They do not have any data related to sort of pesticides, their dangers, level of harming and preparatory measures they ought to take some time recently utilize them. Since of these things, tireless or poisonous chemicals are utilized to murder bugs, weeds or for other use which can cause purposefulness or inadvertent introduction. To play down the utilize of harmful pesticides, it is fundamental to make mindfulness among individuals.

A Study of The Geographical Information System (GIS) based Energy Station Identification and Frequency Analysis Using ETA

Ravindra Gupta — 2024-11-06

The energy corporation entity recently pays maximum attention to the environmental and social safe guards associated with its operations. In developing countries mainly suffers to balance the gap between generation and demand for effective operation by the energy utilities. An inadequate transmission capacity, non-uniform location of energy stations may lead to worst consequences when the occurrences of fault and may end up with black out. To overcome the above situation and to improve the stability of such system, In this research proposes a Geographical Information System (GIS) based identification of location of the uncertainty power stations and also a technique called Islanding Scheme to protect the severely affected system by measuring its frequency parameters. The severely disturbed large interconnected power system is divided into number of subsystems with two or more generating buses feeding its nearby loads by disintegrating the tie lines. The sample 50 bus test case system taken from Tamilnadu Electricity Board (TNEB), INDIA to analyze and simulate the results using Electrical Transient Analyzer Program (ETAP) and Geographical Information System (GIS). In this paper, ETAP and GIS effective software tools used for identify the energy station in various locations and analyzing the frequency status of different buses for better operation in electric utilities and thus ensure better management, enhance the improved stability by mapping the data and outage management.

Challenges in Influenza Control and Surveillance in the Republic of Kazakhstan

Mukhlis Hujatullah — 2024-11-02

The COVID-19 pandemic has significantly disrupted the circulation of influenza viruses in Kazakhstan, highlighting the vulnerabilities in the country’s public health infrastructure. This review critically examines the challenges faced in infiltrating and controlling influenza in Kazakhstan, particularly in light of the shifting epidemiological landscape post-pandemic. Key issues include the decline in influenza cases during the pandemic, which complicates the assessment of influenza epidemiology, vaccine effectiveness, and planning of vaccination campaigns. Although part of the Global Influenza Hospital Surveillance Network (GIHSN), Kazakhstan's surveillance systems face data collection, coordination, and public awareness gaps. The review discusses the prevalence of various influenza strains, the impact of zoonotic infections, and the necessity for improved monitoring frameworks. Additionally, the historical context of infectious disease control in Kazakhstan is explored, emphasising the need for enhanced international collaboration and targeted public health strategies. The findings underscore the importance of vaccination and robust surveillance to mitigate the risks of seasonal and pandemic influenza, advocating for a comprehensive approach to safeguard public health in Kazakhstan.

Advances in Transdermal Drug Delivery: The Development of Microneedle Technology for Improved Therapeutic Outcomes

Shivshankar M. Nagrik — 2024-11-14

Transdermal Drug Delivery Systems (TDDS) represent a significant advancement in therapeutic administration by allowing drugs to bypass the gastrointestinal system and first-pass hepatic metabolism, enhancing patient compliance, and enabling sustained drug release. However, traditional TDDS face limitations, including resistance from the skin's natural barrier and limited efficacy in delivering large or hydrophilic molecules. Microneedle (MN) technology offers a breakthrough solution, using minimally invasive micron-sized needles to bypass the stratum corneum, facilitating efficient drug delivery without significant pain or discomfort. This review explores the evolution and recent advancements in microneedle technology, highlighting its role in overcoming the limitations of conventional TDDS. Microneedles have been shown to enhance drug bioavailability, reduce side effects, and expand the range of deliverable therapeutics, including vaccines, insulin, and genetic materials. The development of bioinspired 4D microneedles further extends their application to diagnostics and cosmetic treatments, positioning MNs as a versatile tool in modern medicine. Key sections of the review focus on the types of microneedles—solid, coated, dissolving, hollow, and hydrogel-forming—and their respective fabrication methods, materials, and drug delivery mechanisms. The review also discusses the challenges related to scaling up production, ensuring consistent quality, and regulatory hurdles in achieving clinical approval. Future directions include the integration of microneedles with nanotechnology, combination therapies, and sustainable design, particularly in developing regions where biodegradable materials may address environmental and disposal concerns. The potential for microneedle technology to revolutionize transdermal drug delivery, diagnostics, and therapeutic monitoring is significant, with ongoing research paving the way for multifunctional applications that can reshape patient care and treatment modalities.

Investigation of Phytochemical and Antidepressants Activity of Cinnamon Powder Extract

Santosh Kumar S.R. — 2024-10-31

Neurodegenerative disease is the most common type of mobility issue, but unfortunately, there is now no medication that can alter the course of the disease. We don't know what causes this ailment. In mouse models of Parkinson's disease induced with 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine, the oral administration of cinnamon powder and sodium benzoate may prevent the death of dopaminergic cells, dysregulation of striatal neurotransmitters, and motor impairments. The mechanisms driving its function include controlling autophagy, antioxidant effects, Parkin, DJ-1, and glial cell line-derived neurotrophic factor activation, TLR/NF-κB pathway modulation, and excessive proinflammatory response prevention. Moreover, research carried out in both laboratory and living organism settings has shown that cinnamon extracts may impact the oligomerisation and aggregation of α-synuclein. This article's goal is to discuss recent findings about this phytochemical's potential as a novel treatment for Parkinson's disease (PD). We highlight additional areas of mechanism that require investigation and possible constraints that must be overcome before this phytochemical may be used in PD trials. Neurodegenerative disease is the most common type of mobility impairment, and unfortunately, there is now no medication that can alter this disease.

We don't know what causes this ailment. There has been a recent uptick in interest in medicinal plant use because of the novelty, safety, and relative affordability of this field. The characteristic flavour and aroma of cinnamon, a spice that is often used, may have neuroprotective effects on people with Parkinson's disease (PD) and other neurodegenerative diseases. The essential oils of Cinnamomum species, such as cinnamaldehyde and sodium benzoate, have shown in vitro that they can protect cells from oxidative stress, ROS generation, and autophagy dysregulation. Consequently, these oils may exert a neuroprotective effect. The in vivo evidence suggests that cinnamon powder and sodium benzoate, when administered orally to Parkinson's disease models in mice, may prevent the death of dopaminergic cells, dysregulation of striatal neurotransmitters, and motor deficits. In this essay, we will go over the latest research on this phytochemical and its potential as a novel treatment for Parkinson's disease (PD). Incorporating this phytochemical into experimental PD treatments requires further investigation into additional molecular aspects and the potential overcoming of constraints and obstacles.

Phytochemical Analysis, Antioxidant Activity of Wild Medicinal Plants of Himalayan Range

Prakash Pralhad Sarwade — 2024-10-31

Plants that are indigenous to the Himalayas have been exploited for their therapeutic properties for over 6,500 years. Using their deep knowledge of the local flora and fauna, traditional healers in the region are able to treat a wide variety of maladies with herbal treatments. People who live in rural areas of the Himalayas rely on wild medicinal plants for their health, and we need to do everything in our power to ensure that these plants continue to thrive in the harsh desert climate of the Himalayas. Raw materials that are obtained from wild plants are in high demand all around the world, particularly among pharmaceutical companies, ethnomedics, and practitioners of traditional medicine as well as other medical practitioners. India has been a top exporter of raw herbal medications all over the world. This is mostly due to the number of medicinal plants that can be found in the Himalayas. The aim of this study was to determine the Phytochemical analysis and antioxidant activity of various parts of 20 selected wild medicinal plants, found in the Himalayan regions in India, China, Nepal, Bhutan and Pakistan including Swertia bimaculate, Ficus neriifolia, Rubus treutleri, Periploca calophylla, G. depressa, Buddleja napaulensis, Habenaria edgeworthii, Pyracantha crenulate, Roscoea procera, Allium rubellum, Berberis chitria, Capsella bursa-pastoris, Artemisia maritima, C. glanduliferum, C. distans, Juniperus macropoda, Origanum vulgare, Valeriana jatamansi, Polygonatum verticillatum, Meconopsis aculeate and Fragaria nubicolais. There were several different parts of the species that were examined to determine their total polyphenol, flavonoid, alkaloid, saponin, and tannin concentrations. One fraction of the plant extracts was found to contain a higher quantity of phytochemicals when compared to the other portions. Through the utilisation of the DPPH and FRAP model systems, the antioxidant capacity of a number of different components was assessed. The high-performance liquid chromatography (HPLC) technique can be combined with the DPPH and/or ABTS tests in order to rapidly screen extracts for the presence of active chemicals.

The Impact of AI on Regulatory Compliance and Anti-Money Laundering Efforts in Payment Processing

Lohith Paripati — 2023-10-31

The paper elaborates on how AI is changing the face of regulatory compliance and anti-money laundering initiatives in the industry for processing payments. This can be done with artificial intelligence tools—natural language processing and machine learning algorithms—applied in areas such as document analysis, anomaly detection, and transaction monitoring. The paper points to increased detection rates, reduced false positives, and improved regulatory reporting associated with the use of AI within the KYC process and customer due diligence procedures more generally. It identifies how AI can transform the financial crime prevention landscape while also acknowledging such challenges as explainability, bias mitigation, and ethical concerns. Finally, some potential future paths in this area, like blockchain integration, federated learning, and the creation of more sophisticated explainable AI models for compliance systems, are discussed.

Climate Change Adaptation and Resource Resilience in Semi-Arid Regions: Strategies, Challenges, and Case Studies

Priyanka Rathore — 2024-10-29

Semi-arid regions face unique climate change challenges that threaten local ecosystems, agriculture, and water resources. This review explores climate adaptation strategies, resource resilience practices, and policy interventions tailored to semi-arid ecosystems, with a focus on Rajasthan, India, as a representative region. Key strategies include sustainable water resource management, soil conservation, and climate-smart agriculture. Through case studies and a comparative global analysis, this review underscores the importance of blending traditional and modern practices to enhance resilience and advocates for policy and technological innovation to support sustainable adaptation. Insights gained from this review may serve as a foundation for adaptation strategies applicable to other semi-arid regions globally.

Challenges and Solutions in Testing Mainframe Applications in Modern Banking

Ashwini Shivarudra — 2024-10-28

Because the foundation of their operations is still housed in legacy systems, banks continue to use them. Banks must modify their systems to remain competitive in light of the swift changes in technology and customer needs. Mainframe systems have been an integral part of corporate computing for many years, enabling critical applications across a range of industries, including banking, retail, and healthcare. There is rising interest in leveraging Application Programming Interfaces (APIs) to expose these old apps' data and features, hence accelerating the construction of new applications and maximising their capability and enabling their reuse. Nonetheless, there are several obstacles to overcome in the process of locating and making available APIs for various business use cases. In this study, we examine the difficulties involved in developing APIs for mainframe systems that are no longer in use and suggest a unique architecture to enable communication for a range of use cases. We performed a qualitative poll with nine mainframe developers, whose average experience was fifteen years, to evaluate the efficacy of our methodology. We were able to determine which APIs were candidates and how long it would take to implement them for two industry mainframe applications and the public mainframe application GENAPP thanks to the poll. We create a list of artefacts, such as screens, transactions, business rules, inter-micro service calls, control flow blocks, and data accesses, in order to identify APIs. IBM Watsonx Code Assistant for Z Refactoring Assistant includes an implementation for computing API signatures. We proved the practicality of our technique by running the discovered APIs on an IBM Z mainframe system to assess their accuracy.

Implementing Agile Testing Methodologies in Banking Software Project

Ashwini Shivarudra — 2022-10-31

Agile software development has been increasingly popular in a number of sectors in recent years. Financial businesses are used to this tendency since it requires them to respond to changes in their business environments more swiftly. Agile approaches have emerged to address the limitations of old ones. In response to the ever-changing and dynamic nature of the business environment, software development businesses are increasingly implementing agile methodologies. The word "Agile" originally arose in the disciplines of software development and project management around thirty years ago. It is used to research with wide-ranging implications, and it is utilized at different levels and in different circumstances. Scrum, kanban, large-scale scrum (LeSS), spotify model, continuous integration, Scaled Agile Lean Development (SCALeD), and many more variations of the agile methodology have emerged. Initially implemented at the individual software development and team level, agile has developed into projects, programs, solutions, and portfolios over time, ultimately reaching full-service growth into an enterprise level framework. In order to examine agile methodologies, models, and practices in a less researched area of the banking and financial services industry—from software development and modelling to large-scale case study organization levels—a unique methodology to surveying the literature has been presented in this paper. The study's conclusion outlines the contributing variables, best practices, advantages, and lessons that professionals in the banking and financial services industries may apply to create a simplified, agile deployment.

Influenza A as a True Zoonotic Pathogen: Transmission through Reservoir Hosts

Neyazi Ghulam Rabani — 2024-10-27

Influenza A virus (IAV) represents a considerable global health threat due to its rapid mutation rates and broad host range, facilitating cross-species transmission and enabling the virus to evade immune defenses. This review explores the molecular mechanisms underlying IAV's pathogenicity, focusing on its zoonotic potential through reservoir hosts, such as wild birds and swine. The virus's ability to undergo antigenic shift and drift allows it to continually adapt to new hosts and environments, posing challenges for control and treatment. Current antiviral therapies are limited by the emergence of resistant strains, underscoring the necessity for innovative vaccine development and treatment strategies. By examining IAV's molecular evolution, immune evasion tactics, and transmission dynamics, this review highlights the critical need for enhanced surveillance, improved therapeutic options, and international cooperation to mitigate future outbreaks. A deeper understanding of these processes is essential to inform public health efforts and combat the persistent threat of IAV.

Integrating Non-SAP Systems with SAP Environments on AWS: Strategies for Seamless Operations

Sachin Bhatt — 2023-12-31

This paper comprises a discussion of the implementation of non-SAP systems in relation to SAP environments on AWS with emphasis on issue identification and best practices. Some primary topics for the conversation are middleware and integration platforms and tools, APIs, and data exchanging strategies, AWS Glue and Lambda. This paper reflects on architectural factors and security factors which are crucial for integration. It also offers insights into the modern technologies like Artificial Intelligence, Blockchain, serverless computing and their roles in future integration evolution. The results stress the need for coherence in integration to make it both run smoothly in terms of operations as well as strategically.

AI-Powered Strategies for Addressing Fiber Nonlinearity in High-Capacity Elastic Optical Networks

Hitesh Solanki — 2023-10-31

To fulfill the rising need for high-capacity and flexible communication systems, Elastic Optical Networks (EONs) have emerged as a possible alternative. However, the growing transmission rates and intricate modulation formats in EONs present substantial difficulties, such as fiber nonlinearity, which may deteriorate signal quality and restrict the network's performance. The fundamental components of EONs are fiber Nonlinear Interference (NLI) modeling and monitoring. Traditionally, they were created and studied independently. Furthermore, for heterogeneous dynamic optical networks, the previously suggested approaches' accuracy must still be increased. In this study, we demonstrate how Artificial Intelligence (AI) is used in NLI monitoring and modeling. We specifically propose to measure the drawbacks of the most current fiber nonlinearity estimates using AI approaches. The Gaussian Noise (GN) framework is used as an instance and Binary Differential-Support Vector Machine (BD-SVM) is used to demonstrate an important enhancement. In addition, we suggest combining modeling and monitoring strategies with AI for a more accurate prediction of NLI variation. Extensive simulations with 2411 connections are done to compare and assess the efficacy of various systems. The results of these simulations demonstrate that the AI-aided modeling and monitoring combo works better than other possible solutions.

Advanced Big Data Mining Techniques for Early Detection of Heart Attacks in Clinical Data

Ritesh Chaturvedi — 2023-06-30

Heart attacks are among the most dangerous ailments that people may develop. The key to controlling cardiovascular disease is to compare, contrast, and mine enormous volumes of data in a sequence that may be used to identify, control, and treat persistent problems, such as heart attacks. Forecasting, preventing, monitoring, and diagnosing cardiovascular diseases may be done through huge efficiency via big data analytics, which is well-known in the business sector for its useful application in regulating, comparing, and supervising enormous datasets. Big data technologies or methods used to mine massive databases for information include Hadoop, data mining, and visualization. Those fresh ideas, which have a wide range of uses, might be helpful in several industries, include medical. In this paper, we extend a big data mining pattern using a machine learning method to forecast the frequency of heart attacks from medical databases. Data preprocessing using the z- score normalization and feature extraction using Linear Discriminant Analysis (LDA) and classification using the Improved Random Forest (IRF). We generate enhanced presentation intensity with accuracy, precision, recall, and F- measure throughout the forecast model for heart disease with the IRF.

Harnessing Data Mining for Early Detection and Prognosis of Cancer: Techniques and Challenges

Ritesh Chaturvedi — 2023-02-28

Cancer is one of the leading causes of mortality worldwide. In 2018, there were approximately 1,735,350 new instances of cancer identified in the United States alone, and 609,640 individuals passed away as a direct result of the disease. Cancers include skin melanoma, lung bronchus cancer, breast cancer, prostate cancer, colon and rectum cancer, bladder cancer, kidney and renal pelvis cancer, and others. Cancer has risen to prominence in the scientific community due to the wide variety of cancers and the enormous number of people it affects. There is still active research on cancer prevention and diagnostic strategies. Using data mining methods, we sought to create a reliable and workable system for cancer diagnosis. Machine learning techniques may assist professionals in creating tools that enable early cancer detection. To improve cancer diagnosis rates, this research aims to introduce a novel machine learning method called the Elephant herding optimized logistic regression (EHOLR) strategy. Histogram equalization (HE) was used for preprocessing the acquired cancer data, and linear discriminant analysis (LDA) was used to extract the data's features. Finally, cancer detection is accomplished using our recommended strategy. The effectiveness of the suggested strategy is then assessed using the performance matrix, namely accuracy, recall, and precision.

A Review on Green Synthesized Metal Nanoparticles Applications

Santosh Kumar S.R. — 2024-10-23

Nanotechnology pertains to the manipulation of materials at exceedingly small scales, specifically between 1 and 100 nanometers. Materials at this scale exhibit significantly different properties compared to the same materials at larger scales. An emerging trend is the utilization of nanoparticles (NPs) to address environmental issues. Metallic nanoparticles are among the several nanoparticles that are extensively utilized in environmentally sustainable endeavors. A sustainable, economical, and enduring approach is to synthesize nanoparticles through a more ecologically friendly procedure instead of a physical or chemical method. Plant components primarily function as reducing and capping agents in eco-friendly synthesis. Diverse metallic nanoparticles of various sizes and shapes have been created utilizing extracts from plant materials, including leaves, bark, fruits, and flowers. The synthesis of Nobel laureate metal nanoparticles is essential to the medical sector. A diverse array of glycosides and phenolic compounds constitutes numerous organic constituents in plants, facilitating the synthesis of metal nanoparticles. The absence of detrimental by-products in metal nanoparticle synthesis is the primary significance of green synthesis. The nanoparticles generated by an eco-friendly approach demonstrate several significant biological activity. A substantial body of literature demonstrates that the synthesized nanoparticles are efficacious against both gram-positive and gram-negative bacteria, including E. coli, Bacillus subtilis, Klebsiella pneumoniae, and Pseudomonas fluorescens. The synthesized nanoparticles not only display antifungal efficacy against several cancer cell lines, including those of breast cancer, but also demonstrate antifungal activity against Trichophyton simii, Trichophyton mentagrophytes, and Trichophyton rubrum. Moreover, they exhibit potent antioxidant properties. The dimensions and morphology of these metal nanoparticles substantially influence their functionalities. Particles characterized by a large surface area and diminutive size provide significant potential for medical applications. This paper aims to provide a comprehensive summary of current advancements in the synthesis of nanoparticles utilizing biological entities and their numerous potential applications.

Role of Herbal Essential Oil in Cervical Cancer: A Systematic Review

Shailendra Sah — 2024-10-22

Cancer of the cervix is a disease that is ubiquitous and frequently severe, and it affects women all over the world. Conventional treatment methods, which include surgical procedures, chemotherapy, and radiation therapy, have been shown to dramatically enhance survival rates; nevertheless, these methods are frequently accompanied with adverse effects and difficulties that might have an influence on the quality of life of a patient. In recent years, there has been a growing interest in the utilisation of essential oils in the cancer treatment and management of cervical cancer. This review offers a comprehensive investigation into the function that various essential oils play in the development of cervical cancer. It also includes insights into the possible advantages of these oils as well as the body of research that has been conducted on them. Additionally, the analysis dives into the future directions and issues that will be faced in this developing industry, with a particular focus on advancements in delivery methods and interesting research areas. For the purpose of enhancing the anticancer qualities of essential oils, the encapsulation of essential oils with solid lipid nanoparticles, the nanoemulsification of essential oils, or the combining of essential oils with conventional treatments have all demonstrated promising results. This review attempts to provide a comprehensive viewpoint, balancing the potential of these natural therapies with the obstacles and issues that need to be addressed. As the employment of essential oils in the treatment or management of cervical cancer continues to develop, this study will attempt to provide a comprehensive perspective. The study will attempt to strike a balance between the potential of these natural treatments and the obstacles and issues that need to be addressed.

Examining the Impact of Climate Change on Agriculture Products in the Province of Jawzjan (Case Study: Certain Villages in Sheberghan City)

Mohammad Ayoob MAKHDOM — 2024-10-11

A region's weather and climate patterns are impacted by climate change over an extended period of time. Rising temperatures, altered precipitation patterns, rising sea levels and other modifications to meteorological conditions are some of these changes. Numerous facets of existence, including the environment, economy, and human communities, may be significantly impacted by climate change. Significant repercussions of climate change are possible, particularly in the agricultural sector. The production of food crops may be impacted by these changes because agricultural goods are dependent on local climate and weather. Pests and plant diseases may also become more prevalent due to climate change. Accordingly, higher temperatures and changed precipitation patterns can foster the growth of pests and illnesses, which will lower agricultural yields. Investigating how climate change affects agricultural products in Sheberghan City, Jawzjan Province, is the goal of this study. A questionnaire was used in fieldwork to perform this study. Six communities inside Sheberghan City—Toka, Qowchin, Jalalabad, Seshanba, Nokar Abad, and Afghan Tapa—were given 100 questionnaires in all. Four different types of questionnaires were produced and designed for the survey portion of this study. Of the 100 responders, 26 worked as farmers, 37 as gardeners, 8 as teachers, and 29 as traders in agricultural products. Using the SPSS26 program, the research was analyzed. The results showed that agricultural goods are significantly impacted by climate change, highlighting the significance of agriculture and agricultural products in the economy. The research findings indicate that the utilization of contemporary technology, such as smart irrigation systems and smart systems, can be one of the elements in growing agricultural products, and that the development of climate-adaptive agricultural methods can boost agricultural products. Farmers' interest can also be raised by government encouragement and assistance. The general conclusion that can be drawn from looking at the aforementioned elements is that agricultural products have been impacted by climate change and the creation of farmers' techniques for adapting to it.

Therapeutic Potential of Quercetin and their Compound Against Ovarian Cancer: New Approaches & Application

M. Duraipandian — 2024-10-11

Ovarian cancer is an exceptionally perilous form of cancer as it develops within the female reproductive system. Finding effective therapy platforms for ovarian cancer has been difficult because to the diverse array of molecular pathways and genetic alterations involved in its development. Therefore, it is imperative to discover novel therapeutic methodologies and advance their development. Medicinal herbs possess the capacity to independently or in combination with other pharmaceuticals, effectively treat malignancies such as ovarian cancer. Quercetin possesses remarkable anti-inflammatory and anti-cancer properties, making it one among numerous natural compounds with such qualities. Quercetin has demonstrated cytotoxicity against ovarian cancer cells in both laboratory experiments (in vitro) and live animal tests (in vivo). The potential anti-cancer effects of quercetin, particularly in relation to ovarian cancer, have not been extensively studied in human trials, despite encouraging findings from laboratory and animal experiments. Hence, it seems that quercetin could potentially be utilized in clinical trials as a therapeutic agent, either on its own or in conjunction with other chemotherapeutic drugs. This article will outline the primary aspects of quercetin's anti-cancer characteristics and thereafter concentrate on its application in the treatment of ovarian cancer.

Effects of Exercise on Hormones in Women with Polycystic Ovary Syndrome

Kavita Narayan Gaisamudre (Sarwade) — 2024-10-11

Numerous reproductive-aged women are impacted by polycystic ovary syndrome (PCOS), an endocrine-gynecology condition. While a risk factor for polycystic ovarian syndrome (PCOS) has been identified, much about the disease's origins and pathophysiology is still up in the air. We searched PubMed and ClinicalTrials.gov extensively for results pertaining to the utilisation of repurposed pharmaceuticals in order to acquire information about the causes and treatments of polycystic ovarian syndrome (PCOS) for this study. We looked at everything that could be causing polycystic ovary syndrome. In addition, the data for both the most commonly prescribed PCOS medications and those that have been repurposed are summarised in the tables. Insulin resistance, inflammation, environmental toxicants, epigenetics, oxidative stress, hyperandrogenism, stress, and nutrition were all part of the internal components that were reviewed. Altering one's way of life and making use of complementary and alternative medicine is often the first line of defence against illness for many people. There is some evidence that certain medications and supplements may be effective in treating polycystic ovarian syndrome (PCOS). These chemicals include mucolytic medicines, thiazolidinediones, sodium-glucose cotransporter-2 inhibitors, dipeptidyl peptidase-4 inhibitors, 3-hydroxy-3-methyl-3-glutaryl-coenzyme A (HMG-CoA) reductase inhibitors, and glucose-like peptide-1 receptor agonists.

DSM Systems for Multi-Processor Architectures Using AI-Driven Test Case Generation

Devendra Arya — 2022-10-31

This research paper explores the critical domain of automated. It also examines automated test execution frameworks, real-time monitoring solutions, and advanced verification and validation techniques. The findings of this study contribute to the advancement of DSM testing methodologies and provide valuable insights for both researchers and practitioners in the field of distributed systems and parallel computing. The research highlights the challenges faced in DSM testing, such as scalability issues and non-determinism, and proposes future directions for research, including the integration of artificial intelligence and cloud-based testing platforms.

Cross-Domain Transfer Learning for Demand Forecasting: Using Social Media Sentiment from Related Industries

Sweta Kumari — 2022-06-30

This study examines various window-based techniques, including time-based, size-based, and hybrid approaches, and evaluates their effectiveness in improving extract performance. Through extensive analysis and empirical testing, we demonstrate that window-based strategies can significantly reduce processing time and resource utilization while maintaining data consistency and integrity. This research paper investigates the application of window-based refresh strategies to enhance the performance of data extracts in large-scale data management systems. Traditional extract, transform, load (ETL) processes often struggle with the increasing volume and velocity of data in modern environments. Window-based refresh strategies offer a promising solution by focusing on specific subsets of data during each refresh cycle. This paper shall be devoted to assessing the efficiency of window-based refresh strategies related to the issues described above. The primary research goals are: Propose a general framework with which to apply window-based refresh strategies during the data extract process. Assess the performance benefits derived from applying different types of approaches based on window-based forms as opposed to conventional full and incremental extracts.

Self-Supervised Learning for Demand Forecasting Using Sparse and Noisy Social Media Sentiment Data

Rekha Singh — 2022-06-30

This research work focuses on the foundational principles of SLO monitoring, architectural considerations for high-volume data processing systems, and advanced techniques for implementing and scaling SLO monitoring solutions. The research includes areas like metric selection, instrumentation techniques, data collection strategies, statistical analysis, and emerging trends in the field. It is a synthesis of current literature and industry practices that presents an organized guide for organizations that want to implement robust SLO monitoring in their data processing infrastructure.

Morphometric Characterization of Nematode Parasites Infecting Periplaneta americana in Bulandshahr, Uttar Pradesh

Anjani Rani — 2022-06-30

This study investigates the morphometric characterization and distribution of nematode parasites infecting Periplaneta americana in Bulandshahr, Uttar Pradesh. The research aimed to identify the nematode species prevalent in various environments and analyze their impact on cockroach populations. Specimens of P. americana were collected from diverse sites, including sewage areas, urban kitchens, and garbage dumps, and examined for nematode infections. The study identified three primary nematode species—Rhabditis blumi, Heterorhabditis bacteriophora, and Steinernema carpocapsae—through microscopic and morphometric analyses. Statistical analysis revealed a significant correlation between environmental factors such as moisture and organic matter availability with nematode prevalence. The highest parasite load was found in sewage areas, where cockroaches exhibited behavioral changes and increased mortality. These findings suggest that parasitic nematodes play a crucial role in controlling P. americana populations, particularly in heavily contaminated environments. The study also highlights the potential use of entomopathogenic nematodes in integrated pest management strategies as an eco-friendly alternative to chemical pesticides. The research contributes to a better understanding of the ecological and biological significance of nematode parasitism in cockroaches and its implications for public health, emphasizing the need for sustainable pest control measures in urban environments.

Building Resilient Data Ingestion Pipelines for Third-Party Vendor Data Integration

Balachandar Paulraj — 2022-04-30

In this report, the author provides a review of the design and operation of the resilient data ingestion architecture with a particular emphasis on the issues associated with third-party data vendor integration. As more and more companies have made information a principal factor in their business strategies, it has become equally imperative to obtain external data in a coherent manner. This paper describes ways of handling Enhanced Data Ingestion Reliability Efficiency and Adaptability and other challenges such as Data quality Error Handling and Scalability.

Effect of Different Levels of Nitrogen, Phosphorus and Potassium Fertilizers on Yield of Cucumber (Cucumis sativus L.) Under The Climatic Conditions of Takhar Province

Abdul Bari Andeshmand — 2024-10-18

The experiment was carried out in the research farm of Agriculture Faculty, Takhar University under the title of the effect of nitrogen fertilizer with different amounts of phosphorus and potassium fertilizers on cucumber yield under the climatic conditions of Takhar Province, Afghanistan. The experiment was laid out in a Randomized Complete Block Design (RCBD) with three replications and four treatments. Treatments T₁ without of any fertilizer, T₂ nitrogen 80 kg ha^-1, phosphorus fertilizer 100 kg ha^-1, and potassium fertilizer 85 kg ha^-1. T₃ nitrogen fertilizer 80 kg ha^-1, phosphorus fertilizer 120 kg ha^-1and potassium fertilizer 95 kg ha^-1. T₄ nitrogen fertilizer 80 kg ha^-1, phosphorus fertilizer 140 kg ha^-1and potassium fertilizer 105 kg ha^-1. In the order of information related to fruit length, fruit diameter, weight per fruit, weight per plant, fruit yield per hectare in tons was registered. The maximum fruit length (19.39 cm), fruit diameter (4.80 cm), weight per fruit (184.87 gr), fruit weight per plant (2.86 kg) and performance per hectare (61.37 tons) in T₄ with nitrogen fertilizer 80 kg ha^-1, phosphorus fertilizer 140 kg ha^-1and potassium fertilizer 105 kg ha^-1were found, while the lowest recorded data was from T₁ i.e. control. From this experiment, it can be said that the use of NPK fertilizer with the use of 80 kg of nitrogen fertilizer ha^-1, 140 kg of phosphorus fertilizer ha^-1 and 105 kg of potassium fertilizer ha^-1 for cucumber cultivation caused better growth and performance in the field of Takhar University.