A Review on Solid Dispersion

Authors

  • Kaur Sharanpreet Assistant Professor, Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial College of Pharmacy, Bela, Rupnagar, Punjab, INDIA.
  • Bhatti Farhan Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial College of Pharmacy, Bela, Rupnagar, Punjab, INDIA.
  • Amisha Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial College of Pharmacy, Bela, Rupnagar, Punjab, INDIA.
  • Kumar Abhishek Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial College of Pharmacy, Bela, Rupnagar, Punjab, INDIA.

DOI:

https://doi.org/10.55544/jrasb.3.2.45

Keywords:

Solid dispersion, solubility, polymers, amorphous

Abstract

The majority of patients prefer to take their medications orally. However, many drugs' limited usage in oral administration is a result of their poor solubility. One important element that influences the rate of dissolution and bioavailability is solubility. Increasing the pace at which weakly water-soluble substances dissolve through solid dispersion is useful. medicines, hence affecting its bioavailability. This study focuses on different approaches to solid dispersion preparation, their benefits and significant difficulties.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

References

Kumar R, Singh A, Salwan R, Bhanot R, Rahar S and Dhawan RK,GSC Bilogical and pharmaceutical sciences,2023,22(01),114-121.

Amidon GL, Lennernas H, Shah VP and Crison JR (1995). Theoretical basis for a biopharmaceutical drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability. Pharm Res., 12(3): 413-420.

Savjani K, Gajjar A, Savjani J. Drug solubility: Importance and enhancement Technique. ISRNP. 2012, 1-10.

Lobenberg R, Amidon GL. Modern bioavailability, bioequivalence and biopharmaceutical classification system.New scientific approaches to international regulatory standards. Eur J Pharm Sci. 2000, 50(1):3–20.

Singh et al, A review on solid dispersion, IJPLS, 2011, 2(9), 1078-1095.

Chaudhary A, Nagaich U, Gulati N, et al. Enhancement of solubilization and bioavailability of poorly soluble drugs by physical and chemical modifications. J Adv Pharm Technol Res. 2012, 2(1):32–67.

Dixit AK., Singh RP, solid dispersion – A strategy for improving the solubility of poorly soluble drugs, IJRPBS, 2012, 3(2), 960-966.

Blagden N, Gavan P, York P. Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates. Adv Drug Del Rev. 2007, 59(30):617–630.

Dhirendra K, Lewis S, Udupa N, et al. Solid Dispersions: A Review. Pak J Pharm Sci. 2009, 22(2):234–246.

Giliyar C, Fikstad DT, Tyavanagimatt S. Challenges and opportunities in oral delivery of poorly water soluble drugs. Pharm Dev Technol. 2006, 6:57–63.

Hsu CH, Cui Z, Mumper RJ, et al. Micellar Solubilization of Some Poorly Soluble Antidiabetic Drugs. AAPS Pharm Sci Tech. 2008, 9(2):431–436.

Huang Y, Dai WG. Fundamental aspects of solid dispersion technology for poorly soluble drugs. Acta Pharm Sin B. 2014, 4(1):18–25.

Janssens S, Mooter GV. Review: physical chemistry of solid dispersions. J Pharm Pract. 2009, 61(12):1571–1586.

Sareen S, Mathew G, Joseph L. Improvement in solubility of poor water-soluble drugs by solid dispersion. Int J Pharma Inv. 2012, 2: 12-17.

Bulau H, Ulrich J. Parameters Influencing the Properties of Drop-Formed Pastilles. In: Ulrich J, editor. Crystal Growth of Organic Materials. Vol. 87. Aachen, Germany: Shaker Verlag, 1997, 123-30.

Serajuddin ATM. Solid dispersion of poorly water-soluble drugs: early promises, subsequent problems, and ecent breakthroughs. J Pharm Sci. 1999, 88(10):1058–1066.

Leuner C, Dressman J. Improving drug solubility for oral delivery using solid dispersions. Eur J Pharm Biopharm. 2000, 50(1):47–60.

Yamashita K, Nakate T, Okimoto KA, et al. Establishment of new preparation method for solid dispersion formulation of tacrolimus. Int J Pharm. 2003, 267:79–91.

Dixit et al, A review- solid dispersion,2014, World Journal of Pharmacy and Pharmaceutical Sciences, 3(9), 238-257.

Hulsmann S, Backensfeld T, Keitel S, et al. Melt extrusion–an alternative method for enhancing the dissolution rate of 17 β-estradiol hemihydrate. Eur J Pharm Biopharm. 2000, 49:237–242.

Kendre P, Chaudhari P. Effect of polyvinyl caprolactam-polyvinyl acetate– polyethylene glycol graft copolymer on bioadhesion and release rate property of eplerenone pellets, Drug DevInd Pharm. 2016, 43: 751-761.

Arunprasad K, Narayanan N, Rajalakshmi G. Preparation and Evaluation of solid Dispersion of Terbinafine Hydrochloride. IJPSRR. Aug 2010, 3: 130- 134.

Huang S, O’donnell K, Keen J, Rickard M, Mcginity J, Williamsiii R. A new extrudable form of Hypromellose: Affinisol™ HPMC HME. AAPS Pharmscitech. 2016, 17: 114-119.

Pandey M, Jaipal A, Charde S, Goel P, Kumar L. Dissolution enhancement of felodipine by amorphous nanodispersions using an amphiphilic polymer: insight into the role of drug-polymer interactions on drug dissolution. Pharm Dev Technol. 2015, 1-12.

Rao M, Mandage Y, Thanki K, Bhise S. Dissolution Improvement of Simvastatin by Surface Solid Dispersion Technology. Dissolution Technologies. 2010, 27- 34.

Sarkar B, Jain D, Agarwal A, Panwar A. Effect of sustained release solid dispersions on dissolution of poorly soluble drug. AJBPS. 2011, 1: 08-10.

Sun D, JuT, Lee P. Enhanced kinetic solubility profiles of indomethacin amorphous solid dispersions in poly(2-hydroxyethyl methacrylate) hydrogels. Eur J Pharm Biopharm. 2012: 81: 149-158.

Pande V, Sanklecha V, AroteS. Formulation and development of extended release matrix pellets of water insoluble AzilsartanMedoxomil with solid dispersion. Indian drugs. 2019, 56: 21-30.

Liebenberg W, Villiers MM, Wurster DE, et al. The effect of polymorphism on powder compaction and dissolution properties of chemically equivalent oxytetracycline hydrochloride powders. Drug Dev Ind Pharm. 1999, 25(9):1027–1033.

Pandya RB, Mehta TA, Gohel MC. Solid dispersion adsorbate-a novel technique for dissolution enhancement of febuxostat. Int J Pharm Sci Res. 2015, 6(10):4236–4242.

Pouton CW. Formulation of poorly water soluble drugs for oral administration :physicochemical and physiological issues and the lipid formulation classification system. Eur J Pharm Sci. 2006, 29(3-4):278–287.

Patrick JM, Tonglei L, Lynne ST. Estimation of Drug–Polymer Miscibility and Solubility in Amorphous Solid Dispersions Using Experimentally Determined Interaction Parameters. Pharm Res. 2009, 26(1):133–139.

Sultana S, Saifuddin AHM. Solid dispersion currently practiced in pharmaceutical field. IJOART. 2016, 5(3):170–175.

Downloads

Published

2023-05-25

How to Cite

Kaur, S., Bhatti, F., Amisha, & Kumar, A. (2023). A Review on Solid Dispersion. Journal for Research in Applied Sciences and Biotechnology, 3(2), 295–300. https://doi.org/10.55544/jrasb.3.2.45

Issue

Section

Articles

Most read articles by the same author(s)