Natural Chemical Constituents and Polymer Used in to Reduce PCOS Pain

Prakash Pralhad Sarwade; B Dhanasree; Kavita Narayan Gaisamudre (Sarwade); Rohit Kumar; Anish Banerjee; Sneha Arunkumar Dubey; Mihir Otia; Vikas Kumar

doi:10.55544/jrasb.4.1.10

Authors

Prakash Pralhad Sarwade Associate Professor and Head, Department of Botany, Shikshan Maharshi Guruvarya R. G. Shinde Mahavidyalaya, Paranda Dist. Dharashiv (Osmanabad) 413 502, (M.S.) INDIA.
B. Dhanasree Assistant Professor of Biochemistry, Head of the Department, SKP Government College, Ambedkar Nagar, Guntakal, Ananthapuram, Andhra Pradesh, INDIA.
Kavita Narayan Gaisamudre (Sarwade) Assistant Professor, Department of Botany, Shriman Bhausaheb Zadbuke Mahavidyalaya, Barshi Tal. Barshi, Dist- Solapur 413401 Maharashtra, INDIA.
Rohit Kumar Associate Professor, Department of Pharmacy Practice, Sri Indu Institute of Pharmacy, Sheriguda (v) Ibrahimpatnam (M) R.R. 501510, Telangana, INDIA.
Anish Banerjee Phase 2 MBBS Student, Maharaja Jitendra Narayan Medical College and Hospital Coochbehar, West Bengal-736101, INDIA.
Sneha Arunkumar Dubey Assistant Professor, Department of Biotechnology, VIVA College of Arts Commerce and Science, Virar West, INDIA.
Mihir Otia MBA, University of east London, London, UNITED KINGDOM.
Vikas Kumar Assistant Professor, Faculty of Pharmacy Bhagwant Global University, Kotdwar Uttarakhand, INDIA.

DOI:

https://doi.org/10.55544/jrasb.4.1.10

Keywords:

Chemical constituent, Polymer, PCOS, pain relief

Abstract

The complex metabolic and endocrine disorder known as polycystic ovarian syndrome (PCOS) is characterised by anovulation, infertility, obesity, insulin resistance, and polycystic ovaries. Factors that predispose women to polycystic ovarian syndrome encompass dietary and lifestyle decisions, environmental pollutants, genetic predisposition, gut dysbiosis, alterations in neuroendocrine function, and excess adiposity. Hyperinsulinemia, oxidative stress, hyperandrogenism, inadequate folliculogenesis, and irregular menstrual periods are symptoms that may arise from these variables, potentially contributing to an escalation of metabolic syndrome. Pathogenic dysbiosis of the gut microbiota may have a role in the aetiology of polycystic ovarian syndrome (PCOS). Immature oocytes, insulin resistance, hyperandrogenism, inflammation, oxidative stress, and resveratrol are pathological features of PCOS that may be ameliorated by supplementation with natural compounds such as polyphenols, quercetin, resveratrol, flavonoids, vitamin C, gamma-linolenic acid, piperine, and omega-3 fatty acids, along with natural and semi-synthetic polymers. This review encapsulates the current understanding of the efficacy of natural chemical supplementation in the treatment of PCOS.

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