Distribution of ABO/Rhesus Blood Groups Among Hepatitis B and C Virus (HBV Ag, HCV Ab) Positive Patients in Anbar Providence, Iraq

Mohammed Khairullah Mahmood; Abdullah Abdulsattar Raeef

doi:10.55544/jrasb.3.2.11

Authors

Mohammed Khairullah Mahmood Ministry of Health, Anbar Health Directorate, Anbar Governorate, IRAQ.
Abdullah Abdulsattar Raeef Al-Maarif University College, Anbar Governorate, 31001, IRAQ.

DOI:

https://doi.org/10.55544/jrasb.3.2.11

Keywords:

ABO, Hepatitis B, Hepatitis C, Viral infection, Transfusion-Transmissible Infections

Abstract

This study aimed to retrospectively investigate the prevalence of Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) infections among blood donors at Anbar Blood Bank in Iraq. The study also explored the correlation between ABO and Rh blood groups with Transfusion-Transmissible Infections (TTIs) and sociodemographic factors and cross-sectional retrospective study was conducted on 100 blood donors at Anbar Blood Bank from March 24, 2023, to June 21, 2023. Inclusion criteria encompassed HBV and HCV-positive patients who provided consent, while exclusion criteria included individuals without HBV and HCV infections. Blood samples (5 mL) were collected, and tests for TTI markers (HBV, HCV) and ABO and Rh blood grouping were performed using enzyme-linked immunosorbent assay (ELISA) and slide method, respectively. Sociodemographic data, TTI marker results, and ABO and Rh blood types were recorded for analysis. Descriptive analysis of sociodemographic data was performed, and a chi-square test was employed to assess the correlation between ABO and Rh blood groups with TTI markers and sociodemographic factors (Age, sex, and living area). Statistical significance was set at P<0.05. The results revealed a male predominance (71%), with the majority aged between 20-30 years (39%) and residing in rural areas (52%). The most common blood group was O+ (39%), while AB- was the least prevalent (0%). In terms of viral infections, 80% of participants were found to be infected with HBs Ag, and 20% with HCV Ab. Notably, blood group O+ exhibited the highest infection rates for both HBs (28%) and HCV (11%), while blood group A- demonstrated the lowest HBs infection rate (3%) and no HCV infection. The study provides valuable insights into the prevalence of HBV and HCV infections among blood donors in Anbar, Iraq. Additionally, correlations between ABO and Rh blood groups, TTI markers, and sociodemographic factors were explored. The findings contribute to the understanding of transfusion safety and may inform blood screening and donor selection protocols.

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References

Terrault, N. A., Lok, A. S., McMahon, B. J., Chang, K. M., Hwang, J. P., Jonas, M. M., ... & Wong, J. B. (2018). Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance. Hepatology, 67(4), 1560-1599.‏

Pirtle, E. C., & Beran, G. W. (1991). Virus survival in the environment. Rev Sci Tech, 10(3), 733-748.‏

Trépo, C., Chan, H. L., & Lok, A. (2014). Hepatitis B virus infection. The Lancet, 384(9959), 2053-2063.‏

Abegaz, S. B. (2021). Human ABO blood groups and their associations with different diseases. BioMed research international, 2021, 1-9.‏

Paquette, M., Dufour, R., & Baass, A. (2018). ABO blood group is a cardiovascular risk factor in patients with familial hypercholesterolemia. Journal of Clinical Lipidology, 12(2), 383-389.‏

Huang, J. Y., Wang, R., Gao, Y. T., & Yuan, J. M. (2017). ABO blood type and the risk of cancer–Findings from the Shanghai Cohort Study. PloS one, 12(9), e0184295.‏

Lao, T. T., Sahota, D. S., Chung, M. K., Cheung, T. K. W., Cheng, Y. K. Y., & Leung, T. Y. (2014). Maternal ABO and rhesus blood group phenotypes and hepatitis B surface antigen carriage. Journal of viral hepatitis, 21(11), 818-823.‏

Liu, J., Zhang, S., Liu, M., Wang, Q., Shen, H., & Zhang, Y. (2018). Distribution of ABO/Rh blood groups and their association with hepatitis B virus infection in 3.8 million Chinese adults: a population‐based cross‐sectional study. Journal of viral hepatitis, 25(4), 401-411.‏

Mohammadali, F., & Pourfathollah, A. (2014). Association of ABO and Rh blood groups to blood-borne infections among blood donors in Tehran-Iran. Iranian journal of public health, 43(7), 981.‏

Szmuness, W., Prince, A. M., & Cherubin, C. E. (1971). Serum hepatitis antigen (SH) carrier state: relation to ABO blood groups. British Medical Journal, 2(5755), 198.‏

Szmuness, W. R. A. R. E. H., Hirsch, R. L., Prince, A. M., Levine, R. W., Harley, E. J., & Ikram, H. (1975). Hepatitis B surface antigen in blood donors: further observations. Journal of Infectious Diseases, 131(2), 111-118.‏

Behal, R., Jain, R., Behal, K. K., Bhagoliwal, A., Aggarwal, N., & Dhole, T. N. (2008). Seroprevalence and risk factors for hepatitis B virus infection among general population in Northern India. Arquivos de gastroenterologia, 45, 137-140.‏

World Health Organization. (2016). Global health sector strategy on viral hepatitis 2016-2021. Towards ending viral hepatitis (No. WHO/HIV/2016.06). World Health Organization.‏

Yamamoto, F., Cid, E., Yamamoto, M., Saitou, N., Bertranpetit, J., & Blancher, A. (2014). An integrative evolution theory of histo-blood group ABO and related genes. Scientific reports, 4(1), 6601.‏

Yamamoto, F., Cid, E., Yamamoto, M., & Blancher, A. (2012). ABO research in the modern era of genomics. Transfusion medicine reviews, 26(2), 103-118.‏

Alireza, E. N., Mojtaba, R., & Sahar, E. N. (2010). Chronic viral hepatitis and their relation to ABO blood groups and rhesus (Rh) factor. Medical Case Studies, 1(1), 5-7.

‏ Poujol-Robert, A., Boelle, P. Y., Wendum, D., Poupon, R., & Robert, A. (2006). Association between ABO blood group and fibrosis severity in chronic hepatitis C infection. Digestive diseases and sciences, 51, 1633-1636.‏

Legese, B., Shiferaw, M., Tamir, W., Eyayu, T., Damtie, S., Berhan, A., ... & Solomon, Y. (2022). Association of ABO and rhesus blood types with transfusion-transmitted infections (ttis) among apparently healthy blood donors at bahir Dar blood bank, bahir Dar, North West, Ethiopia: a retrospective cross-sectional study. Journal of Blood Medicine, 581-587.‏

Prakash, S., Sahoo, D., Mishra, D., Routray, S., Ray, G. K., Das, P. K., & Mukherjee, S. (2020). Association of transfusion transmitted infections with ABO and Rh D blood group system in healthy blood donors: a retrospective analysis. Int. J. Community Med. Public Heal, 7, 4444-4448.‏

SB KV, B. S., Kondareddy, S., & Madithadu, A. (2015). Association of ABO and Rh blood groups to HBV, HCV infections among blood donors in a blood bank of tertiary care teaching hospital in Southern India: A retrospective study. Int J Res Med Sci, 3(7), 1672-1676.