Biological Benefits of Diallyl Disulfide, A Garlic-Derived Natural Organic Sulfur Compound

Amle Vandana Sonaji; Ade Rajkumar Pradeep; Chapke Sima Ganesh; Dudhate Gitanjali Sambhaji; Anamika; Roshan Kumar; Amir Nurdini Mziray; Edward Amoah Boateng; Richard Owusu Nyarko; Paul Owusu Boateng

doi:10.55544/jrasb.3.1.24

Authors

Amle Vandana Sonaji Shri Bhairavnath Nisarg Mandal's Diploma in Pharmacy Institute, Hingoli Maharashtra INDIA.
Ade Rajkumar Pradeep Shri Bhairavnath Nisarg Mandal's Diploma in Pharmacy Institute, Hingoli Maharashtra INDIA.
Chapke Sima Ganesh Shri Bhairavnath Nisarg Mandal's Diploma in Pharmacy Institute, Hingoli Maharashtra INDIA.
Dudhate Gitanjali Sambhaji Shri Bhairavnath Nisarg Mandal's Diploma in Pharmacy Institute, Hingoli Maharashtra INDIA.
Anamika Shree Dev Bhoomi Institute of Education, Science & Technology, Village Mazhon, P.O. Poundha, Via, Prem Nagar, Dehradun, Uttarakhand 248001, INDIA.
Roshan Kumar Shree Dev Bhoomi Institute of Education, Science & Technology, Village Mazhon, P.O. Poundha, Via, Prem Nagar, Dehradun, Uttarakhand 248001, INDIA. https://orcid.org/0000-0003-0604-0217
Amir Nurdini Mziray Department of Surgery, Hubert Kairuki Memorial University Hospital, Dar es salaam, TANZANIA.
Edward Amoah Boateng Department of Surgery, St Lukes Hospital, Kasei off Ejura Road, GHANA.
Richard Owusu Nyarko Department of Surgery, Hubert Kairuki Memorial University Hospital, Dar es salaam, TANZANIA.
Paul Owusu Boateng Department of Public Health, School of Graduate Studies, Ghana Institute of Management & Public Administration, Accra, GHANA.

DOI:

https://doi.org/10.55544/jrasb.3.1.24

Keywords:

DADS, Garlic, Extract, Chemical Compounds

Abstract

There is a possibility that diallyl disulfide and diallyl trisulfide can alleviate neuropathic pain in rats that have been subjected to CCI. The mechanisms by which these compounds alleviate pain entail an increase in the levels of H2S, BDNF, and Nrf2 in the sciatic nerve and the dorsal root ganglion (DRG). The use of garlic as a functional food and as a great source of pharmacologically active compounds is widely recognised and generally accepted. One of the most important bioactive components of garlic is called diallyl disulfide (DADS), and it possesses a number of beneficial biological effects. These capabilities include anti-inflammatory, antioxidant, antibacterial, cardiovascular protective, neuroprotective, and anticancer actions. In this review, the biological roles of DADS were reviewed in a systematic manner, and the molecular mechanisms that underlie these functions were explored. We have high hopes that this review will not only offer direction and insight into the existing body of literature, but will also make it possible for future study and the development of DADS for the intervention and treatment of other disorders.

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References

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