Investigation of In- Vitro Method of Antiulcer Activity

Roshan Kumar

doi:10.55544/jrasb.2.1.37

Authors

Roshan Kumar Assistant Professor, Department of Pharmacology, Guru Nanak College of Pharmaceutical Sciences, Dehradun, INDIA.

DOI:

https://doi.org/10.55544/jrasb.2.1.37

Keywords:

Gastrointestinal, Ulcer, In vitro methods, Herbal extract

Abstract

It has long been known that medicinal plants include traditional therapeutic ingredients for the treatment and prevention of illnesses and disorders. In order to find out if hydroalcoholic extracts of fenugreek seeds may be used to treat ulcers, this study tested the extracts' capacity to neutralize acids and their ability to block H+/K+ - ATPase. A 1000 mg/ml concentration of the Seeds extract significantly reduced the acidity from 11.90 at the normal 500 mg/ml of Aluminium hydroxide + Magnesium hydroxide to 6.10. The maximum percentage of inhibition of the H+/K+ - ATPase was shown by petals extract at a concentration of 400 g/ml, which is less than the typical dose of esmoprazole (73.82%). The IC 50 value of extract of fenugreek seeds is shown to be 100 g/ml when compared to the average dose of esmoprazole, which is 82.5 g/ml. According to the findings of this study, fenugreek seeds contain compounds that have the ability to neutralize acids and block enzymes, making them a potential alternative treatment for digestive problems.

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References

Das, S., Singh, V. D., Bind, A., Anamika, A., Gupta, S. P., & Kumar, R. (2022). Evaluation of antiulcer, antioxidant potency of manuka honey and cinnamon powder mixture in Wistar rats using experimental rat models. International Journal of Health Sciences, 6(S6), 6259–6268. https://doi.org/10.53730/ijhs.v6nS6.10979

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Afzaal, M., Saeed, F., Ateeq, H., Akhtar, M. N., Imran, A., Ahmed, A., ... & Awuchi, C. G. (2022). Probiotics encapsulated gastroprotective cross-linked microgels: Enhanced viability under stressed conditions with dried apple carrier.

Kumar, R., Saha, P., Kahwa, I., Boateng, E. A., Boateng, P. O., & Nyarko, R. O. (2022). Biological Mode of Action of Phospholipase A and the Signalling and Pro and Anti-Inflammatory Cytokines: A Review. Journal of Advances in Medicine and Medical Research, 34(9), 1-10.

Mishra, A., Singh, Y., Singh, R., Kumar, R., Shukla, S., Kumar, R., ... & Pol, S. L. (2022). Ethano-pharmacology activity & Antioxidant activity of Centella asiatica Plant Parts. NEUROQUANTOLOGY, 20(11), 7562-2.

Singhal, A. K. V., Giri, S., & Kumar, R. (2022). INVESTIGATION OF IN-VITRO ANTI-OXIDANT & ANTI-ULCER ACTIVITY OF ANGIOGENESIS LATIFOLIA ROXB (DHAVA). NeuroQuantology, 20(11), 5680-5686.

Chaudhary, H., Sagar, S., Kumar, R., Bisht, V., & Butola, K. (2022). Herbal Essential Oil use as Ulcer Protective Activity: A Systematic Review. Journal for Research in Applied Sciences and Biotechnology, 1(5), 86-101.

Prajapati, A. K., Sagar, S., & Kumar, R. (2022). Past and Current Prospectives of Herbal Product for Skin Care. Journal for Research in Applied Sciences and Biotechnology, 1(5), 145-160.

Kumar, R., Singh, A., & Painuly, N. (2022). Investigation of in-vitro anti-oxidant & anti-ulcer activity of polyherbal medicinal plants. Journal of Pharmaceutical Negative Results, 2077-2088.

Awuchi, C. G., Saha, P., Amle, V. S., Nyarko, R. O., Kumar, R., Boateng, E. A., ... & Asum, C. (2023). A Study of Various Medicinal Plants used in Ulcer Treatment: A Review. Journal for Research in Applied Sciences and Biotechnology, 2(1), 234-246.

Kohli, A., & Kumar, R. (2023). Role of Antioxidants of Natural Herbs in Management of Male Infertility. Journal for Research in Applied Sciences and Biotechnology, 2(1), 55-80.

Kumar, R., & Saha, P. (2022). A review on artificial intelligence and machine learning to improve cancer management and drug discovery. International Journal for Research in Applied Sciences and Biotechnology, 9(3), 149-156.

Patel, R. K., Gangwar, D., Gupta, H., Sharma, N., & Kumar, R. (2023). Plants Alkaloids Based Compound as Therapeutic Potential for Neurodegenerative. Journal for Research in Applied Sciences and Biotechnology, 2(2), 14-26.

Bind, A., Das, S., Singh, V. D., Kumar, R., Chourasia, A., & Saha, P. (2020). Natural Bioactives For The Potential Management Of Gastric Ulceration. Turkish Journal of Physiotherapy and Rehabilitation, 32(3), 221-226

Saha, P., Kumar, R., Nyarko, R. O., Kahwa, I., & Owusu, P. (2021). Herbal Secondary Metabolite For Gastro-Protective Ulcer Activity With Api Structures.

Kumar, R., Saha, P., Kahwa, I., Boateng, E. A., Boateng, P. O., & Nyarko, R. O. (2022). Biological Mode of Action of Phospholipase A and the Signalling and Pro and Anti Inflammatory Cytokines: A Review. Journal of Advances in Medicine and Medical Research, 34(9), 1-10.