Evaluation of Cafeteria Diet in Experimental Animal with Plant Extract of Calotropis procera for Obesity Parameter

Richard Owusu Nyarko; Chinaza Godswill Awuchi; Roshan Kumar; Edward Boateng; Ivan Kahwa; Paul Owusu Boateng; Christian Asum; Purabi Saha

doi:10.55544/jrasb.1.3.14

Authors

Richard Owusu Nyarko School of Medicine, American International University of West Africa, THE GAMBIA.
Chinaza Godswill Awuchi School of Natural and Applied Sciences, Kampala International University, Box 20000, Kampala, UGANDA.
Roshan Kumar Department of Pharmacology, Dev Bhoomi Institute of Pharmacy and Research, Dehradun, Uttarakhand, INDIA.
Edward Boateng Department of Surgery, Komfo Anokye Teaching Hospital, Kumasi, GHANA.
Ivan Kahwa Pharm-Biotechnology and Traditional Medicine Center (Pharmbiotrac), ACE II, Mbarara University of Science and Technology, P.O Box 1410, Mbarara, UGANDA.
Paul Owusu Boateng Department of Medicine, Family Tree Medical Centre Accra, GHANA.
Christian Asum School of Medicine, American International University of West Africa, THE GAMBIA.
Purabi Saha Department of Pharmacy, Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, Uttarakhand, INDIA.

DOI:

https://doi.org/10.55544/jrasb.1.3.14

Keywords:

obesity, Herbal medication, hunger, Kalhari cactus

Abstract

The function of obesity in an insulin-resistant syndrome associated with hyper insulinemia, hypertension, hyperlipidemia, atherosclerotic diseased illness is vital. Hunger, body weight and lipid profile investigations thus assess Calotropis procera extract in animal models.

Adult Wister rats (180-240g) 8 were used in each experimental group. The impact of Cactus Kalahari on hunger, body weight and profile of lipids. (A) Control in weight, (B) obesity and CP+ obesity. Control obesity caused by material of cafeteria cuisine (CD). (CP was induced at (100 mg/kg/day po. for 50 days). Every 10 days, the food give, animal body weight, blood glucose, serum lipids level examined—serum and term tests for Liver Function and Renal Function Tests were checked.

Our research has demonstrated that following obesity induction CP pretreatment and administration at 100mg/kg/day p<0.05) have resulted in substantial reductions in food consumption, increased body weight and improved lipid profile, liver enzyme and kidney function tests. Cafeteria food rats also showed considerable growth in body weight gain, famine, lipid profile, hepatic enzymes, and kidney function tests.

When administered with a protein-rich food at the same time, the Kalahari extract prevented and reduced body weight gain and profile of lipid alterations in experimental induced obesity(fats) in rats.

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References

Awuchi, C. G., Amagwula, I. O., Priya, P., Kumar, R., Yezdani, U., & Khan, M. G. (2020). Aflatoxins in foods and feeds: A review on health implications, detection, and control. Bull. Environ. Pharmacol. Life Sci, 9, 149-155.

Umama, Y., Venkatajah, G., Shourabh, R., Kumar, R., Verma, A., Kumar, A., & Gayoor, M. K. (2019). Topic-The scenario of pharmaceuticals and development of microwave as; sisted extraction technique. World J Pharm Pharm Sci, 8(7), 1260-1271.

Kumar, R., Saha, P., Lokare, P., Datta, K., Selvakumar, P., & Chourasia, A. (2022). A Systemic Review of Ocimum sanctum (Tulsi): Morphological Characteristics, Phytoconstituents and Therapeutic Applications. International Journal for Research in Applied Sciences and Biotechnology, 9(2), 221-226.

Roshan, K. (2020). Priya damwani, Shivam kumar, Adarsh suman, Suthar Usha. An overview on health benefits and risk factor associated with coffee. International Journal Research and Analytical Review, 7(2), 237-249.

Dubey, A., Yadav, P., Verma, P., & Kumar, R. (2022). Investigation of Proapoptotic Potential of Ipomoea carnea Leaf Extract on Breast Cancer Cell Line. Journal of Drug Delivery and Therapeutics, 12(1), 51-55.

Sahana, S. (2020). Purabi saha, Roshan kumar, Pradipta das, Indranil Chatterjee, Prasit Roy, Sk Abdur Rahamat. A Review of the 2019 Corona virus (COVID-19) World Journal of Pharmacy and Pharmaceutical science, 9(9), 2367-2381

Bind, A., Das, S., Singh, V. D., Kumar, R., Chourasia, A., & Saha, P. Natural Bioactives For The Potential Management Of Gastric Ulceration. Turkish Journal of Physiotherapy and Rehabilitation, 32(3).

Nyarko, R. O., Prakash, A., Kumar, N., Saha, P., & Kumar, R. (2021). Tuberculosis a globalized disease. Asian Journal of Pharmaceutical Research and Development, 9(1), 198-201.

Raj, A., Tyagi, S., Kumar, R., Dubey, A., & Hourasia, A. C. (2021). Effect of isoproterenol and thyroxine in herbal drug used as cardiac hypertrophy. Journal of Cardiovascular Disease Research, 204-217

Kumar, R., & Dubey, A. PHYTOCHEMICAL INVESTICATION AND HEPTOPROTECTIVE EVALUTION ACACIA RUBICA EXTRACT ISONIZED AND PARACETAMOL INDUSED ANIMAL TOXICITY. Turkish Journal of Physiotherapy and Rehabilitation, 32(3).

Singh, M. K., Kumar, A., Kumar, R., Kumar, P. S., Selvakumar, P., & Chourasia, A. (2022). Effects of Repeated Deep Frying on Refractive Index and Peroxide Value of Selected Vegetable Oils. International Journal for Research in Applied Sciences and Biotechnology, 9(3), 28-31.

Saha, P., Kumar, R., Nyarko, R. O., Kahwa, I., & Owusu, P. (2021). HERBAL SECONDARY METABOLITE FOR GASTRO-PROTECTIVE ULCER ACTIVITY WITH API STRUCTURES.

Nyarko, R. O., Kumar, R., Sharma, S., Chourasia, A., Roy, A., & Saha, P. (2022). ANTIBACTERIAL ACTIVITY OF HERBAL PLANT-TINOSPORA CORDIFOLIA AND CATHARNTHUS ROSEUS.

Sahana, S., Kumar, R., Nag, S., Paul, R., Chatterjee, I., & Guha, N. (2020). A REVIEW ON ALZHEIMER DISEASE AND FUTURE PROSPECTS

Sahana, S. (2020). Roshan kumar, Sourav nag, Reshmi paul, Nilayan guha, Indranil Chatterjee. A Review on Alzheimer disease and future prospects. World Journal of Pharmacy and Pharmaceutical science, 9(9), 1276-1285.

Nyarko, R. O., Saha, P., Kumar, R., Kahwa, I., Boateng, E. A., Boateng, P. O., ... & Bertram, A. (2021). Role of Cytokines and Vaccines in Break through COVID 19 Infections. Journal of Pharmaceutical Research International, 33, 2544-2549.

PURABISAHA, R. K., RAWAT, S. S. N., & PRAKASH, A. (2021). A REVIEW ON NOVEL DRUG DELIVERY SYSTEM.

Nyarko, R. O., Boateng, E., Kahwa, I., & Boateng, P. O. (2020). A comparison analysis on remdesivir, favipiravir, hydroxychloroquine, chloroquine and azithromycin in the treatment of corona virus disease 2019 (COVID-19)-A Review. World J. Pharm. Pharm. Sci, 9, 121-133.

KUMAR, R., SAHA, P., SARKAR, S., RAWAT, N., & PRAKASH, A. (2021). A REVIEW ON NOVEL DRUG DELIVERY SYSTEM. IJRAR-International Journal of Research and Analytical Reviews (IJRAR), 8(1), 183-199

Nyarko, R. O., Boateng, E., Kahwa, I., Boateng, P. O., & Asare, B. (2020). The impact on public health and economy using lockdown as a tool against COVID-19 pandemic in Africa: a perspective. J Epidemiol Public Health Rev, 5(3).

Kumar, R., Saha, P., Pathak, P., Mukherjee, R., Kumar, A., & Arya, R. K. EVOLUTION OF TOLBUTAMIDE IN THE TREATMENT OF DIABETES MELLITUS. Jour. of Med. P’ceutical & Alli. Sci, 9.

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Saha, P., Nyarko, R. O., Lokare, P., Kahwa, I., Boateng, P. O., & Asum, C. (2022). Effect of Covid-19 in Management of Lung Cancer Disease: A Review. Asian Journal of Pharmaceutical Research and Development, 10(3), 58-64.

Kumar, R., Jain, A., Tripathi, A. K., & Tyagi, S. (2021, January). Covid-19 outbreak: An epidemic analysis using time series prediction model. In 2021 11th international conference on cloud computing, data science & engineering (Confluence) (pp. 1090-1094). IEEE

KUMAR, A. (2019). The Scenario of Pharmaceuticals and Development of Microwave Assisted Extraction Techniques.

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Nalimu, F., Oloro, J., Kahwa, I., & Ogwang, P. E. (2021). Review on the phytochemistry and toxicological profiles of Aloe vera and Aloe ferox. Future Journal of Pharmaceutical Sciences, 7(1), 1-21.

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Bhati, V., Yadav, P. K., & Kumar, R. (2018). Effect of Levels of Inorganic Fertilizers, Organic Manure and Bio-Fertilizers on Plant Growth Attributes of Onion (Allium cepa L.) cv. N-53 under Hot Arid Region of Western Rajasthan, India. International J. Curr. Micro. Appl. Sci, 7, 3593-601.

Bugga, P., Alam, M. J., Kumar, R., Pal, S., Chattopadyay, N., & Banerjee, S. K. (2022). Sirt3 ameliorates mitochondrial dysfunction and oxidative stress through regulating mitochondrial biogenesis and dynamics in cardiomyoblast. Cellular Signalling, 94, 110309.

Kumar, S., Yadav, S. P., Chandra, G., Sahu, D. S., Kumar, R., Maurya, P. S., ... & Ranjan, K. (2019). Effect of dietary supplementation of yeast (Saccharomyces cerevisiae) on performance and hemato-biochemical status of broilers.

Dubey, A., Kumar, N., Mishra, A., Singh, Y., & Tiwari, M. (2020). Review on Vinpocetine. International Journal of Pharmacy & Life Sciences, 11(5).

Saha, P., Kumar, A., Bhanja, J., Shaik, R., Kawale, A. L., & Kumar, R. (2022). A Review of Immune Blockade Safety and Antitumor Activity of Dostarlimab Therapy in Endometrial Cancer. International Journal for Research in Applied Sciences and Biotechnology, 9(3), 201-209.

Anubhav, S. P. D., Sanjay, K. D., & Roshan, K. (2022). Evaluation of Enzyme Producing K. Pneumoniae and Their Susceptibility to Other Anti-Biotics. International Journal of Innovative Science and Research Technology2022, 7(5), 351-353.

Kumar, R., Saha, P., Keshamma, E., Sachitanadam, P., & Subramanian, M. (2022). Docking Studies of Some Novel Hetrocyclic Compound as Acat Inhibitors: A Meta Analysis. Journal for Research in Applied Sciences and Biotechnology, 1(3), 33-41.

Pandey, M., Singh, A., Agnihotri, N., Kumar, R., Saha, P., Pandey, R. P., & Kumar, A. (2022). Clinical Pharmacology & Therapeutic uses of Diuretic Agents: A Review. Journal for Research in Applied Sciences and Biotechnology, 1(3), 11-20.

Amle, V. S., Rathod, D. A., Keshamma, E., Kumar, V., Kumar, R., & Saha, P. (2022). Bioactive Herbal Medicine Use for Eye Sight: A Meta Analysis. Journal for Research in Applied Sciences and Biotechnology, 1(3), 42-50.

Kumar, R., Keshamma, E., Paswan, S. K., Saha, P., Trivedi, U., Chourasia, A., & Otia, M. (2022). Alkaloid Based Chemical Constituents of Ocimum santum & Cinchona Bark: A Meta Analysis. Journal for Research in Applied Sciences and Biotechnology, 1(2), 35-42.

Singh, Y., Paswan, S. K., Kumar, R., Otia, M. K., Acharya, S., Kumar, D., & Keshamma, E. (2022). Plant & Its Derivative Shows Therapeutic Activity on Neuroprotective Effect. Journal for Research in Applied Sciences and Biotechnology, 1(2), 10-24

Nyarko, R. O., Roopini, R., Raviteja, V., Awuchi, C. G., Kumar, R., Faller, E. M., ... & Saha, P. (2022). Novel Sars-CoV-2 Variants & Therapeutic Effects. Journal for Research in Applied Sciences and Biotechnology, 1(2), 25-34.