Role of Biotechnology in Combating Antibiotic Resistance

Deepak Panwar

doi:10.55544/jrasb.3.6.21

Authors

Deepak Panwar Plant Molecular Virology Lab Department of Genetics and Plant Breeding, Chaudhary Charan Singh University Meerut Campus, 250004, INDIA.

DOI:

https://doi.org/10.55544/jrasb.3.6.21

Keywords:

Phage Therapy, CRISPR-Cas Systems, Rapid Diagnostic Tools, Antimicrobial Peptides (AMPs)

Abstract

Antibiotic resistance (AR) has emerged as one of the most pressing global health threats of the 21st century. The overuse and misuse of antibiotics have accelerated the emergence of resistant bacterial strains, rendering conventional treatments less effective. In this context, biotechnology has a crucial role to play in combating antibiotic resistance by enabling the development of new antibiotics, alternative therapies, diagnostic tools, and strategies for better stewardship of existing antibiotics. This paper explores the role of biotechnology in addressing antibiotic resistance, focusing on the innovative approaches such as the discovery of novel antibiotics, antimicrobial peptides, bacteriophage therapy, CRISPR-based technologies, and biosensors. Additionally, we discuss the importance of a multidisciplinary approach and the challenges faced in implementing these solutions at a global scale.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

References

Davies, J., & Davies, D. (2010). Origins and evolution of antibiotic resistance. Microbiology and Molecular Biology Reviews, 74(3), 417-433.

Walsh, C. (2003). Where will new antibiotics come from? Nature Reviews Microbiology, 1(1), 65-70.

Hancock, R. E., & Sahl, H. G. (2006). Antimicrobial peptides: Towards clinical applications. Nature Reviews Drug Discovery, 6(3), 285-296.

Barros, M. D. (2016). The role of CRISPR-Cas systems in combating bacterial infections. Trends in Microbiology, 24(12), 1012-1024.

Hyman, P., & Abedon, S. T. (2010). Bacteriophage host range and bacterial resistance. Advances in Applied Microbiology, 70, 217-248.

Iglewski, B. H., & Ramphal, R. (2019). Diagnostic methods for antibiotic-resistant bacterial infections. Clinical Microbiology Reviews, 32(4), e00083-18.

O'Neill, J. (2016). Tackling Drug-Resistant Infections Globally: Final Report and Recommendations. Review on Antimicrobial Resistance, Wellcome Trust.

Liu, Y. Y., et al. (2016). Emergence of the NDM-1 superbug in the clinic. The Lancet Infectious Diseases, 16(4), 379-387.

Mahalingam, S., et al. (2018). Advances in Biotechnology for Combatting Antibiotic Resistance: A Review. Antibiotics, 7(4), 73.

Baquero, F., et al. (2015). Antibiotics and Antibiotic Resistance in the Environment: A Review. Science of the Total Environment, 532, 69-91.

Zong, Z., et al. (2017). Bacteriophage therapy: a potential treatment of multidrug-resistant bacteria. Frontiers in Microbiology, 8, 1-8.

Ventola, C. L. (2015). The Antibiotic Resistance Crisis: Part 1: Causes and Threats. P&T, 40(4), 277-283.