Clinicopathology & Molecular Analysis of Diffuse Intrinsic Pontine Glioma (DIPG) in Children - Insights from Past, Present, and Future Directions

Arupam Biswas

doi:10.55544/jrasb.1.4.8

Authors

Arupam Biswas Student of Five Years Integrated M.Sc. in Life Sciences, Integrated Science Education and Research Centre, Visva-Bharati (A Central University & An Institution of National Importance), Santiniketan- 731235, INDIA.

DOI:

https://doi.org/10.55544/jrasb.1.4.8

Keywords:

Diffuse Intrinsic Pontine Glioma (DIPG), pediatric High-Grade Glioma (pHCG), H3K27M-Mutant

Abstract

Diffuse Intrinsic Pontine Glioma, or DIPG, is a rare, highly aggressive, heterogeneous group of brainstem tumors. Around 10-20% of primary brain tumors are considered pediatric brain tumors, of which 10-15% are diffuse brainstem tumors. It is considered untreatable and surgically unremovable due to its intrinsic position within the brain. Over the years, applying radiotherapy and chemotherapy has not shown a better outcome. However, gene-targeted therapy has proven successful, but it is still in the developing phase. This article covers the various aspects of DIPG, from clinical and molecular definitions to a vision for a universally accepted novel approach to beat this severe condition by joining fundamental science and translational research.

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